16281-94-0

Basic information

• Product Name: 4-BROMOMETHYL-ISOPHTHALIC ACID DIMETHYL ESTER
• Synonyms: 4-BROMOMETHYL-ISOPHTHALIC ACID DIMETHYL ESTER;DiMethyl 4-(broMoMethyl)isophthalate;1,3-Benzenedicarboxylic acid, 4-(broMoMethyl)-, 1,3-diMethyl ester
• CAS NO: 16281-94-0
• Molecular Formula: C₁₁H₁₁BrO₄
• Molecular Weight: 287.11
• Mol File: 16281-94-0.mol
• Article Data: 9

Chemical Properties

• Appearance: /
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 4-BROMOMETHYL-ISOPHTHALIC ACID DIMETHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 4-BROMOMETHYL-ISOPHTHALIC ACID DIMETHYL ESTER(16281-94-0)
• EPA Substance Registry System: 4-BROMOMETHYL-ISOPHTHALIC ACID DIMETHYL ESTER(16281-94-0)

Safety Data

• Hazardous Substances Data: 16281-94-0(Hazardous Substances Data)

Usage

General Description

4-Bromomethyl-isophthalic acid dimethyl ester is a chemical compound with the molecular formula C11H12BrNO4. It is a dimethyl ester derivative of 4-bromomethyl-isophthalic acid, which is commonly used in the synthesis of various organic compounds. This chemical is a white to pale yellow crystalline powder and is primarily utilized as an intermediate in the production of pharmaceuticals, agrochemicals, and other fine chemicals. It is also used in the manufacturing of polymers and resins. Additionally, it is known to have potential applications in the field of materials science due to its unique molecular structure and reactivity. However, caution should be exercised when handling this chemical due to its potential hazards, and it should only be used by trained professionals in appropriate laboratory settings.

Upstream product

• 128-08-5 N-Bromosuccinimide 
• 23038-61-1 dimethyl 4-methylbenzene-1,3-dicarboxylate 
• 95-73-8 2,4-dichlorotoluene 
• 2094-98-6 1,1'-azobis (cyclohexanecarbonitrile) 
• 3347-99-7 4-methyl isophthalic acid 
• 7697-26-9 3-bromo-4-methylbenzoic acid 

Downstream Products

• 877380-04-6 dimethyl 4-({[6-(5-phenyl-1H-pyrrol-2-yl)-2-naphthyl]oxy}methyl)isophthalate 
• 877380-02-4 dimethyl 4-{[(6-{5-phenyl-1-[4-(trifluoromethyl)benzyl]-1H-pyrrol-2-yl}-2-naphthyl)oxy]methyl}isophthalate 

Relevant articles and documents

Nonpeptide GPIIB/IIIA inhibitors. 10. Centrally constrained alpha-sulfonamides are potent inhibitors of platelet aggregation

Potency enhancing features of two series of fibrinogen receptor antagonists were combined to give analogs with improved potency and oral activity. Antagonists containing either alkyl or aryl sulfonamides and a central isoindolinone structural constraint demonstrate high affinity for both activated and unactivated platelet receptors.

SMALL MOLECULE DEGRADERS OF HELIOS AND METHODS OF USE

Disclosed are compounds and pharmaceutically acceptable salts, hydrates, solvates, prodrugs, stereoisomers, or tautomers thereof that may cause degradation of various proteins e.g., IKZF2 (Helios). Also disclosed are pharmaceutical compositions containing

Design, Synthesis, and Biological Evaluation of Novel Type I1/2 p38α MAP Kinase Inhibitors with Excellent Selectivity, High Potency, and Prolonged Target Residence Time by Interfering with the R-Spine

We recently reported 1a (skepinone-L) as a type I p38α MAP kinase inhibitor with high potency and excellent selectivity in vitro and in vivo. However, as a type I inhibitor, it is entirely ATP-competitive and shows just a moderate residence time. Thus, the scope was to develop a new class of advanced compounds maintaining the structural binding features of skepinone-L scaffold like inducing a glycine flip at the hinge region and occupying both hydrophobic regions I and II. Extending this scaffold with suitable residues resulted in an interference with the kinase's R-Spine. By synthesizing 69 compounds, we could significantly prolong the target residence time with one example to 3663 s, along with an excellent selectivity score of 0.006 and an outstanding potency of 1.0 nM. This new binding mode was validated by cocrystallization, showing all binding interactions typifying type I1/2 binding. Moreover, microsomal studies showed convenient metabolic stability of the most potent, herein reported representatives.