Nonpeptide GPIIB/IIIA inhibitors. 10. Centrally constrained alpha-sulfonamides are potent inhibitors of platelet aggregation

Article abstract of DOI:10.1016/0960-894X(96)00473-8

Potency enhancing features of two series of fibrinogen receptor antagonists were combined to give analogs with improved potency and oral activity. Antagonists containing either alkyl or aryl sulfonamides and a central isoindolinone structural constraint demonstrate high affinity for both activated and unactivated platelet receptors.