162811-08-7

Upstream product

• 56-40-6 glycine 
• 207982-87-4 4-(4-chlorobenzylidene)-2-(4-methylpiperazin-1-yl)-1H-imidazol-5(4H)-one 
• 280137-25-9 2-thioxo-5-(4-chlorophenylmethylidene)-4-imidazolidinone 

Downstream Products

• 162713-48-6 1-acetyl-6-(4-chlorobenzylidene)-2,3,5,6-tetrahydroimidazo<2,1-b>imidazole-3,5-dione 
• 162713-44-2 ethyl N-<5-(4-chlorobenzylidene)-4-oxo-2-imidazolidinyl>glycinate 

Relevant academic research and scientific papers

Structure and activity studies of glycine receptor ligands. Part 7. Structural remarks on arylidene-imidazoline-4-one glycinates and glycinamides

To improve the physicochemical properties (lipophilicity) of the potential ligands of glycine binding site of NMDA receptor, esters and amides of glycine derivatives of arylidene-imidazolidine-4-ones were obtained. The analysis of their properties (X-ray crystallography, NMR spectral data and theoretical calculations) was performed with respect to the existence of the probable tautomeric forms. Their possible interaction with hypothetical active points of the receptor (taking into the account the model of glycine binding site of NMDA receptor) was discussed on the basis of simulation with IsoStar. program.