162848-18-2

Basic information

• Product Name: 4-MORPHOLINOBENZOYL CHLORIDE HYDROCHLORIDE
• Synonyms: 4-MORPHOLINOBENZOYL CHLORIDE HYDROCHLORIDE;4-MorpholinobenzoylchlorideHCl;4-MORPHOLINOBENZOYL CHLORIDE;4-(morpholin-4-yl)benzoyl chloride;4-(Morpholin-4-yl)benzoyl chloride hydrochloride
• CAS NO: 162848-18-2
• Molecular Formula: C₁₁H₁₂ClNO₂
• Molecular Weight: 262.13
• Mol File: 162848-18-2.mol
• Article Data: 14

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-MORPHOLINOBENZOYL CHLORIDE HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-MORPHOLINOBENZOYL CHLORIDE HYDROCHLORIDE(162848-18-2)
• EPA Substance Registry System: 4-MORPHOLINOBENZOYL CHLORIDE HYDROCHLORIDE(162848-18-2)

Safety Data

• Hazardous Substances Data: 162848-18-2(Hazardous Substances Data)

Usage

General Description

4-Morpholinobenzoyl chloride hydrochloride is a chemical compound that is used in organic synthesis and pharmaceutical research. Its molecular structure consists of a chlorinated benzene ring attached to a morpholine group, which contains a nitrogen atom and an oxygen atom in a ring structure. 4-MORPHOLINOBENZOYL CHLORIDE HYDROCHLORIDE is reactive and can be used to introduce the morpholine group into various organic molecules, making it a versatile building block for the synthesis of new compounds. It is important to handle this compound with care, as it is a corrosive and potentially hazardous material.

Upstream product

• 79-37-8 oxalyl dichloride 
• 7470-38-4 4-morpholin-4-yl-benzoic acid 
• 30483-75-1 4-bromophenyl-morpholine 
• 141-75-3 butyryl chloride 

Downstream Products

• 23676-05-3 4-morpholin-4-yl-benzoic acid methyl ester 
• 10282-31-2 4-morpholinobenzonitrile 
• 1369525-56-3 2-hydroxy-N-(4-morpholinobenzoyl)benzamide 
• 1311050-40-4 N-ethyl-4-(morpholino)benzamide 
• 1379773-08-6 N-ethyl-2-iodo-4-(morpholino)benzamide 
• 1327167-31-6 N-(3-(3-[(phenylsulfonyl)amino]phenyl)-1H-pyrazol-5-yl)-4-morpholinobenzamide 

Relevant articles and documents

Structure-Activity Study of Nitazoxanide Derivatives as Novel STAT3 Pathway Inhibitors

We identified nitazoxanide (NTZ) as a moderate STAT3 pathway inhibitor through immunoblot analysis and a cell-based IL-6/JAK/STAT3 pathway activation assay. A series of thiazolide derivatives were designed and synthesized to further validate the thiazolide scaffold as STAT3 inhibitors. Eight out of 25 derivatives displayed potencies greater than that of NTZ, and their STAT3 pathway inhibitory activities were found to be significantly correlated with their antiproliferative activities in HeLa cells. Derivatives 15 and 24 were observed to be more potent than the positive control WP1066, which is under phase I clinical trials. Compared with NTZ, 15 also exhibited much improved in vivo pharmacokinetic parameters in rats and efficacies against proliferations in multiple cancer cell lines, indicating a broad-spectrum effect of these thiazolides as antitumor agents targeted on STAT3.

Palladium-Catalyzed Chlorocarbonylation of Aryl (Pseudo)Halides Through In Situ Generation of Carbon Monoxide

An efficient palladium-catalyzed chlorocarbonylation of aryl (pseudo)halides that gives access to a wide range of carboxylic acid derivatives has been developed. The use of butyryl chloride as a combined CO and Cl source eludes the need for toxic, gaseous carbon monoxide, thus facilitating the synthesis of high-value products from readily available aryl (pseudo)halides. The combination of palladium(0), Xantphos, and an amine base is essential to promote this broadly applicable catalytic reaction. Overall, this reaction provides access to a great variety of carbonyl-containing products through in situ transformation of the generated aroyl chloride. Combined experimental and computational studies support a reaction mechanism involving in situ generation of CO.

FUSED THIOPHENE DERIVATIVES AND THEIR USES

The present invention relates to a new class of fused thiophene derivatives and their uses for treating diseases such as infection, cancer, metabolic diseases, cardiovascular diseases, iron storage disorders and inflammatory disorders.