PhSO(N-tert-butyldimethylsilyl)CF₂H

Base Information

• Chemical Name: PhSO(N-tert-butyldimethylsilyl)CF₂H
• CAS No.: 1628946-71-3
• Molecular Formula: C₁₃H₂₁F₂NOSSi
• Molecular Weight: 305.464
• Mol file: 1628946-71-3.mol

Synonyms:PhSO(N-tert-butyldimethylsilyl)CF₂H

Chemical Property of PhSO(N-tert-butyldimethylsilyl)CF₂H

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of PhSO(N-tert-butyldimethylsilyl)CF₂H

There total 1 articles about PhSO(N-tert-butyldimethylsilyl)CF₂H which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

(difluoromethyl)(imino)(phenyl)-λ6-sulfanone (1333375-53-3) + tert-butyldimethylsilyl chloride (18162-48-6) → PhSO(N-tert-butyldimethylsilyl)CF2H (1628946-71-3)

Guidance literature:

(difluoromethyl)(imino)(phenyl)-λ⁶-sulfanone; With 1H-imidazole; In N,N-dimethyl-formamide; at 20 ℃; for 0.0833333h; Inert atmosphere;

tert-butyldimethylsilyl chloride; In N,N-dimethyl-formamide; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1002/chem.201402506

Reference yield: 94.0%

1-iodo-3-phenylpropan (4119-41-9) + PhSO(N-tert-butyldimethylsilyl)CF2H (1628946-71-3) → N-tert-butyldimethylsilyl-S-1,1-difluoro-4-phenylbutyl-S-phenylsulfoximine

Guidance literature:

With N,N,N,N,N,N-hexamethylphosphoric triamide; lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 0.5h; Inert atmosphere;

DOI:10.1002/cjoc.201400403

Reference yield: 92.0%

ethyl bromide (74-96-4) + PhSO(N-tert-butyldimethylsilyl)CF2H (1628946-71-3) → N-tert-butyldimethylsilyl-S-1,1-difluoropropyl-S-phenylsulfoximine

Guidance literature:

With N,N,N,N,N,N-hexamethylphosphoric triamide; lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 0.5h; Inert atmosphere;

DOI:10.1002/cjoc.201400403

upstream raw materials:

(difluoromethyl)(imino)(phenyl)-λ⁶-sulfanone

tert-butyldimethylsilyl chloride

Downstream raw materials:

C₂₃H₃₃F₂NO₂SSi