1629182-12-2Relevant academic research and scientific papers
Redox-neutral α,β-difunctionalization of cyclic amines
Chen, Weijie,Kang, Youngku,Wilde, Richard G.,Seidel, Daniel
, p. 5179 - 5182 (2014)
In contrast to the continuously growing number of methods that allow for the efficient α-functionalization of amines, few strategies exist that enable the direct functionalization of amines in the β-position. A general redox-neutral strategy is outlined for amine β-functionalization and α,β-difunctionalization that utilizes enamines generated insitu. This concept is demonstrated in the context of preparing polycyclic N,O-acetals from simple 1-(aminomethyl)-β-naphthols and 2-(aminomethyl)-phenols. An unprecedented α,β-difunctionalization reaction of amines affords polycyclic N,O-acetals from simple 1-(aminomethyl)-β-naphthols or 2-(aminomethyl)-phenols. These transformations are redox-neutral and proceed in the absence of any additives.
