162934-76-1

Usage

Uses

Used in Pharmaceutical Industry:
Naphthalen-1-yl(1H-pyrrol-3-yl)methanone is used as a key intermediate in the synthesis of high affinity ligands for the cannabinoid CB1 and CB2 receptors. These ligands are crucial for developing new drugs targeting these receptors, which play a significant role in various physiological processes, including pain, appetite, and immune response regulation. The development of such ligands can lead to innovative treatments for a range of conditions, including chronic pain, obesity, and inflammatory diseases.

Upstream product

• 129667-10-3 3-(1-naphthoyl)-N-(p-toluenesulfonyl)pyrrole 
• 879-18-5 naphthalene-1-carbonic acid chloride 
• 16851-82-4 N-phenylsulfonylpyrrole 
• 20300-10-1 1-naphthalenecarbothioamide 
• 609-41-6 N-acetylpyrrole 

Downstream Products

• 162934-73-8 JWH 030 
• 162934-74-9 (1-hexyl-1H-pyrrol-3-yl)-1-naphthalenylmethanone 

Relevant academic research and scientific papers

Imidazole derivatives having an inhibitory activity for farnesyl transferase and process for preparation thereof

The present invention relates to a novel imidazole derivative represented by formula (1) which shows an inhibitory activity against farnesyl transferase or pharmaceutically acceptable salts or isomers thereof, in which A, n1and Y are defined in the specification; to a process for preparation of the compound of formula (1); to intermediates which are used in the preparation of the compound of formula (1); and to a pharmaceutical composition comprising the compound of formula (1) as an active ingredient.

A study of the Friedel-Crafts acylation of 1-benzenesulfonyl-1H-pyrrole in the preparation of 3-aroylpyrroles

In this work, we studied the aluminum chloride catalyzed reaction of 1- benzenesulfonyl-1H-pyrrole with a series of eleven aroyl chlorides. The products formed were not isolated, but hydrolyzed to the target 3- aroylpyrroles in overall yields, usually, higher than 50%. However, in the CaSeS with the π electron rich 1-phenyl-1H-pyrrole-3-carbonyl chloride and 1-methyl-1H-indole-3-carbonyl chloride significant C-2 substitution occured, resulting in the isolation of the corresponding 1-benzenesulfonyl-2- aroylpyrroles as the predominant or the sole products. The desired C-3 isomers were synthesized starting with 1-triisopropylsilanyl-1H-pyrrole.

The regioselective photoinduced aroylation at the 3-position of pyrrole derivatives

Irradiation of arenecarbothioamide with pyrrole or indole derivatives gave regioselectively 3-aroylpyrrole or -indole derivatives, respectively.

1-Alkyl-3-(l-naphthoyl)pyrroles: A New Class of Cannabinoid

The design and synthesis of a series of 1-alkyl-3-(1-naphthoyl)pyrroles is described. Molecular modeling studies were employed to aid in the design of these compounds. During the course of the synthesis the Friedel-Crafts reactions of N-aryl sulfonyl pyrroles were reinvestigated. The title compounds (4) were subjected to pharmacological evaluation and the data obtained have enabled these pyrroles to be classified as cannabinoids.