609-41-6

Basic information

• Product Name: 1H-Pyrrole, 1-acetyl-
• CAS NO: 609-41-6
• Molecular Formula: C6H7NO
• Molecular Weight: 109.128
• Mol File: 609-41-6.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1H-Pyrrole, 1-acetyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Pyrrole, 1-acetyl-(609-41-6)
• EPA Substance Registry System: 1H-Pyrrole, 1-acetyl-(609-41-6)

Safety Data

• Hazardous Substances Data: 609-41-6(Hazardous Substances Data)

Usage

Structure

A five-membered aromatic ring with one nitrogen atom and an acetyl group attached to the nitrogen atom, resulting in a ketone functional group

Usage

Commonly used as a building block in organic synthesis to create various pharmaceuticals, dyes, and polymers

Potential properties

Studied for its potential anti-inflammatory, anti-cancer, and anti-microbial properties

Applications in materials science

Has been found to have applications in the development of conductive polymers and organic electronic devices.

Upstream product

• 109-97-7 pyrrole 
• 108-24-7 acetic anhydride 
• 7601-90-3 perchloric acid 
• 593-53-3 Methyl fluoride 
• 201230-82-2 carbon monoxide 
• 16199-06-7 potassium pyrrolide 
• 75-36-5 acetyl chloride 
• 99237-86-2 exo-10-acetyl-4-phenyl-4,10-diazatricyclo<5.2.1.0^2,6>dec-8-ene-3,5-dione 

Downstream Products

• 31685-34-4 2,5-diacetylpyrrole 
• 617-92-5 1-ethyl-1H-pyrrole 
• 1072-83-9 2-Acetylpyrrole 
• 109-97-7 pyrrole 
• 64-19-7 acetic acid 
• 99237-87-3 exo-10-acetyl-4-phenyl-4,10-diazatricyclo<5.2.1.0^2,6>decane-3,5-dione 
• 64-17-5 ethanol 
• 71-50-1 acetate 
• 99237-86-2 exo-10-acetyl-4-phenyl-4,10-diazatricyclo<5.2.1.0^2,6>dec-8-ene-3,5-dione 
• 162934-76-1 naphthalen-1-yl(1H-pyrrol-3-yl)methanone 

Relevant articles and documents

Azabicyclic vinyl sulfones for residue-specific dual protein labelling

We have developed [2.2.1]azabicyclic vinyl sulfone reagents that simultaneously enable cysteine-selective protein modification and introduce a handle for further bioorthogonal ligation. The reaction is fast and selective for cysteine relative to other amino acids that have nucleophilic side-chains, and the formed products are stable in human plasma and are moderately resistant to retro Diels-Alder degradation reactions. A model biotinylated [2.2.1]azabicyclic vinyl sulfone reagent was shown to efficiently label two cysteine-tagged proteins, ubiquitin and C2Am, under mild conditions (1-5 equiv. of reagent in NaPi pH 7.0, room temperature, 30 min). The resulting thioether-linked conjugates were stable and retained the native activity of the proteins. Finally, the dienophile present in the azabicyclic moiety on a functionalised C2Am protein could be fluorescently labelled through an inverse electron demand Diels-Alder reaction in cells to allow selective apoptosis imaging. The combined advantages of directness, site-specificity and easy preparation mean [2.2.1]azabicyclic vinyl sulfones can be used for residue-specific dual protein labelling/construction strategies with minimal perturbation of native function based simply on the attachment of an [2.2.1]azabicyclic moiety to cysteine.

Reactions at high pressure. Part 15. Rates, activation parameters, and a volume profile for retro-Diels-Alder reactions in the pyrrole series

Thermal decomposition of N-acylpyrrole adducts of N-phenylmaleimide by a ?2s + ?2s = ?2s> route occurs at temperature below 70 deg C.Rates and activation parameters for the termolyses of endo- and exo-10-benzoyl-4-phenyl-4,10-diazatricyclo2,6>dec-8-ene-3,5-dione (6) and (7), exo-10-acetyl-4-phenyl-4,10-diazatricyclo2,6>dec-8-ene-3,5-dione (8), and endo-4-phenyl-4-aza-10-oxatricyclodec-8-ene-3,5-dione (9) have been measured at various temperatures and pressures and in various solvents.It is confirmed that the volume of activation for thermolysis of (6) is negative, consistent with a transition state more compact than either reagents or products and not accountable for in terms of dipolar character.