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162959-93-5

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162959-93-5 Usage

Description

1-(thiophen-2-yl)cyclopropanecarbonitrile is an organic compound characterized by the presence of a cyclopropane ring fused with a thiophen-2-yl group and a carbonitrile functional group. This unique molecular structure endows it with specific chemical properties that make it a versatile building block in organic synthesis and medicinal chemistry.

Uses

Used in Pharmaceutical Industry:
1-(thiophen-2-yl)cyclopropanecarbonitrile is used as a reactant for the synthesis of quinolines, which are a class of nitrogen-containing heterocyclic compounds with diverse biological activities. In particular, these quinolines serve as P-selectin inhibitors, playing a crucial role in the potential treatment of vascular diseases by modulating the inflammatory response and preventing the adhesion of leukocytes to the endothelium.

Check Digit Verification of cas no

The CAS Registry Mumber 162959-93-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,6,2,9,5 and 9 respectively; the second part has 2 digits, 9 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 162959-93:
(8*1)+(7*6)+(6*2)+(5*9)+(4*5)+(3*9)+(2*9)+(1*3)=175
175 % 10 = 5
So 162959-93-5 is a valid CAS Registry Number.

162959-93-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name 1-thiophen-2-ylcyclopropane-1-carbonitrile

1.2 Other means of identification

Product number -
Other names 1-Thien-2-ylcyclopropanecarbonitrile

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:162959-93-5 SDS

162959-93-5Relevant articles and documents

Chiral Bidentate Boryl Ligand Enabled Iridium-Catalyzed Enantioselective C(sp3)-H Borylation of Cyclopropanes

Shi, Yongjia,Gao, Qian,Xu, Senmiao

supporting information, p. 10599 - 10604 (2019/08/28)

We herein report an Ir-catalyzed enantioselective C(sp3)-H borylation of cyclopropanecarboxamides using a chiral bidentate boryl ligand for the first time. A variety of substrates with α-quaternary carbon centers could be compatible in this reaction to provide β-borylated products with good to excellent enantioselectivities. We have also demonstrated that the borylated products can be used as versatile precursors engaging in stereospecific transformations of C-B bonds, including the synthesis of a bioactive compound Levomilnacipran.

GLP-1 RECEPTOR MODULATORS

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Paragraph 00960, (2016/06/28)

Compounds are provided that modulate the glucagon-like peptide 1 (GLP-1) receptor, as well as methods of their synthesis, and methods of their therapeutic and/or prophylactic use. Such compounds can act as modulators or potentiators of GLP-1 receptor on their own, or with incretin peptides such as GLP-1(7-36) and GLP-1(9-36), or with peptide-based therapies, such as exenatide and liraglutide, and have the following general structure (where "^^^^" represents either or both the R and S form of the compound) (I) where A, B, C, Y1, Y2, Z, R1, R2, R3, R4, R5, W1, n, p and q are as defined herein.

A cascade approach to fused indolizinones through Lewis acid-copper(i) relay catalysis

Huang, Huawen,Ji, Xiaochen,Wu, Wanqing,Jiang, Huanfeng

supporting information, p. 3351 - 3353 (2013/06/04)

A relay catalytic cascade process involving Lewis acid triggered ring-opening of cyclopropyl ketones with nitriles, the copper(i)-catalyzed Ritter process, and acid-promoted N-acyliminium ion cyclization is described, which efficiently provides thieno-, furano-, and benzo-indolizinones in moderate to good yields. The Royal Society of Chemistry 2013.

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