1629601-27-9Relevant academic research and scientific papers
Rh2(OAc)4 and chiral phosphoric acid cocatalyzed highly diastereo- and enantioselective four-component reactions: Facile synthesis of chiral α,β-diamino acid derivatives
Jing, Changcheng,Xing, Dong,Qian, Yu,Hu, Wenhao
supporting information, p. 1348 - 1354 (2014/06/09)
A highly diastereo- and enantioselective four-component reaction of a diazo ketone with two molecules of anilines and ethyl glyoxylate was achieved under Rh2(OAc)4 and chiral phosphoric acid cocatalyzed conditions. This transformation proceeds through a Mannich-type trapping of the ammonium ylide generated from metal carbene and one molecule of aniline with iminoester derived from another molecule of aniline and ethyl glyoxylate. With this method, a series of chiral α,β-diamino acid derivatives were efficiently constructed in good yields and with good to excellent diastereo- and enantioselectivities. Georg Thieme Verlag Stuttgart New York.
