1629730-59-1Relevant articles and documents
Efficient access to 2,6,8-trisubstituted 4-aminoquinazolines through microwave-assisted one-pot chemoselective Tris-Suzuki-Miyaura or SNAr/bis-Suzuki-Miyaura reactions in water
Kabri, Youssef,Crozet, Maxime D.,Terme, Thierry,Vanelle, Patrice
, p. 3806 - 3817 (2015)
An efficient, sequential, one-pot strategy for synthesizing polyfunctionalized quinazoline derivatives is presented. After selective amination of 6,8-dibromo-2,4-dichloroquinazoline at the C-4 position, 2,6,8-trisubstituted 4-aminoquinazoline derivatives
One-pot chemoselective synthesis of 2,4,6,8-tetrasubstituted quinazolines via microwave-assisted consecutive bis-SNAr/Bis-Suzuki-Miyaura cross-coupling reactions
Kabri, Youssef,Crozet, Maxime D.,Redon, Sebastien,Vanelle, Patrice
, p. 1613 - 1620 (2014/06/23)
A practical and efficient synthesis of 2,4,6,8-tetrasubstituted quinazolines through one-pot chemoselective sequential bis-SNAr/bis- Suzuki-Miyaura reactions under microwave irradiation is presented. The bis-SNAr reaction occurs selectively at the C-2 and C-4 positions of 6,8-dibromo-2,4-dichloroquinazoline and the bis-Suzuki-Miyaura cross-coupling at C-6 and C-8. This procedure affords convergent synthesis of polysubstituted quinazoline derivatives in high yields in very few steps and tolerates a wide range of boronic acids and amines.