16307-15-6

Basic information

• Product Name: 2-(4-chlorobenzyl)-2,3-dihydro-1H-inden-1-one
• Synonyms: 2-(4-chlorobenzyl)-2,3-dihydro-1H-inden-1-one
• CAS NO: 16307-15-6
• Molecular Weight: 256.732
• Mol File: 16307-15-6.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 2-(4-chlorobenzyl)-2,3-dihydro-1H-inden-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-chlorobenzyl)-2,3-dihydro-1H-inden-1-one(16307-15-6)
• EPA Substance Registry System: 2-(4-chlorobenzyl)-2,3-dihydro-1H-inden-1-one(16307-15-6)

Safety Data

• Hazardous Substances Data: 16307-15-6(Hazardous Substances Data)

Upstream product

• 62708-42-3 o-allylbenzaldehyde 
• 609-67-6 2-Iodobenzoyl chloride 
• 88-67-5 2-Iodobenzoic acid 
• 195062-61-4 4-chlorophenylboronic acid pinacol ester 
• 104-88-1 4-chlorobenzaldehyde 
• 83-33-0 inden-1-one 
• 5706-17-2 (E)-2-(4-chlorobenzylidene)-indan-1-one 
• 122-01-0 4-chloro-benzoyl chloride 

Downstream Products

• 16307-19-0 C₁₆H₁₅ClO 
• 1180676-93-0 ethyl (E)-2-(2-(4-chlorobenzyl)-2,3-dihydro-1H-inden-1-ylidene)acetate 
• 14798-87-9 {2-[2-(4-Chloro-benzyl)-3H-inden-1-yl]-ethyl}-dimethyl-amine 
• 16392-77-1 2-(4-chlorobenzyl)-indene 

Relevant articles and documents

Iridium-catalyzed chemoselective transfer hydrogenation of α, β-unsaturated ketones to saturated ketones in water

A chemoselective iridium-catalyzed transfer hydrogenation of α, β-unsaturated ketones was realized in water. The C[dbnd]C double bonds of 2-benzylidene indanones and analogues were hydrogenated exclusively catalyzed by an iridium complex (0.1 mol%) bearin

Ni-Catalyzed Alkene Carboacylation via Amide C-N Bond Activation

We report Ni-catalyzed formal carboacylation of o-allylbenzamides with arylboronic acid pinacol esters. The reaction is triggered by oxidative addition of an activated amide C-N bond to a Ni(0) catalyst and proceeds via alkene insertion into a Ni(II)-acyl bond. The exo-selective carboacylation reaction generates 2-benzyl-2,3-dihydro-1H-inden-1-ones in moderate to high yields (46-99%) from a variety of arylboronic acid pinacol esters and substituted o-allylbenzamides. These results show that amides are practical substrates for alkene carboacylation via amide C-N bond activation, and this approach bypasses challenges associated with alkene carboacylation triggered by C-C bond activation.

Cinchona alkaloid catalyzed enantioselective fluorination of allyl silanes, silyl enol ethers, and oxindoles

(Chemical Equation Presented) Catalytic variant: Allyl silanes and silyl enol ethers 1 are good substrates for the catalytic highly enantioselective fluorodesilylation using a combination of a biscinchona alkaloid, N-fluorobenzenesulfonimide (NFSI), and base (see scheme). Pharmaceutically attractive 3-aryl-3-fluorooxindoles such as 3 can also be synthesized with high enantioselectivity.