163070-77-7Relevant articles and documents
Supramolecular Phosphoryl Transfer Reactions Mediated by Amidinium Phosphate Ion-Pair Complexes
Mueller, Gilbert,Duerner, Gerd,Bats, Jan W.,Goebel, Michael W.
, p. 1075 - 1092 (2007/10/02)
In order to build up simplified synthetic models of staphylococcal nuclease two derivatives of 8-phenylnaphthalene-1-carboxamidine equipped with nucleophilic side chains have been prepared (1, 2).After protonation these amidinium alcohols bind phosphodiester anions via hydrogen bonds and react within the ion-pair complexes to give zwitterionic products 27 and 28.The rate accelerations (DMF, 30 deg C) compared to the phosphorylation of noncharged alcohols are 2700-fold (2) and 930-fold (1). - Key Words: Artificial phosphodiesterase / Naphthalene, 1,8-disubstituted / Molecular Recognition / Staphylococcal nuclease, model of / Enzymes / Amidinium phosphate / Ion-Pair Complexes / Guanidine