16311-68-5

Basic information

• Product Name: Thiazolium, 5-(2-hydroxyethyl)-4-methyl-3-(phenylmethyl)-, bromide
• CAS NO: 16311-68-5
• Molecular Formula: C13H16NOS.Br
• Molecular Weight: 314.246
• Mol File: 16311-68-5.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Thiazolium, 5-(2-hydroxyethyl)-4-methyl-3-(phenylmethyl)-, bromide(CAS DataBase Reference)
• NIST Chemistry Reference: Thiazolium, 5-(2-hydroxyethyl)-4-methyl-3-(phenylmethyl)-, bromide(16311-68-5)
• EPA Substance Registry System: Thiazolium, 5-(2-hydroxyethyl)-4-methyl-3-(phenylmethyl)-, bromide(16311-68-5)

Safety Data

• Hazardous Substances Data: 16311-68-5(Hazardous Substances Data)

Upstream product

• 137-00-8 5-hydroxyethyl-4-methylthiazole 
• 100-39-0 benzyl bromide 
• 155709-86-7 3-Benzyl-5-(2-hydroxy-ethyl)-4-methyl-2,3-dihydro-thiazol-2-ol 

Downstream Products

• 52534-31-3 3-benzyl-3a-methyl-1',3',N,N'-tetrakis-(4-nitro-phenyl)-tetrahydro-spiro[furo[2,3-d]thiazole-2,4'-imidazolidine]-2',5'-diylidenediamine 
• 52625-16-8 3-benzyl-2-[N,N'-bis-(4-nitro-phenyl)-carbamimidoyl]-5-(2-hydroxy-ethyl)-4-methyl-thiazolium; bromide 
• 7742-52-1 4-benzyl-6-(2-hydroxyethyl)-5-methyl-2-phenyl-2,3-dihydro-4H-1,4-thiazin-3-one 
• 7742-53-2 2-(4-benzyl-5-methyl-3-oxo-2-phenyl-2,3-dihydro-4H-1,4-thiazin-6-yl)ethyl benzoate 
• 23888-58-6 4,6-dimethyl-2-phenyl-4,6-dihydro-imidazo[4,5-d]thiazole-5-thione 
• 20940-05-0 4-benzyl-6-(2-hydroxy-ethyl)-5-methyl-2-p-tolylimino-4H-[1,4]thiazin-3-one 
• 52625-18-0 3-benzyl-2-[N,N'-bis-(2-nitro-phenyl)-carbamimidoyl]-5-(2-hydroxy-ethyl)-4-methyl-thiazolium; bromide 
• 52534-33-5 3-benzyl-3a-methyl-1',3',N,N'-tetrakis-(2-nitro-phenyl)-tetrahydro-spiro[furo[2,3-d]thiazole-2,4'-imidazolidine]-2',5'-diylidenediamine 
• 20939-96-2 3-benzyl-2-[(4-chloro-phenyl)-thiocarbamoyl]-5-(2-hydroxy-ethyl)-4-methyl-thiazolium betaine 
• 20939-95-1 3-benzyl-5-(2-hydroxy-ethyl)-4-methyl-2-(phenyl-thiocarbamoyl)-thiazolium betaine 
• 52579-95-0 5-(2-hydroxy-ethyl)-3,4-dimethyl-N-p-tolyl-2,3-dihydro-thiazole-2-carboximidic acid 4-methyl-anilide 
• 20940-03-8 3-benzyl-2-(N,N'-di-p-tolyl-carbamimidoyl)-5-(2-hydroxy-ethyl)-4-methyl-thiazolium; bromide 
• 24022-72-8 3-benzyl-1',3'-diethyl-3a-methyl-tetrahydro-spiro[furo[2,3-d]thiazole-2,4'-imidazolidine]-2',5'-dithione 
• 23971-99-5 3-benzyl-3a,1',3'-trimethyl-tetrahydro-spiro[furo[2,3-d]thiazole-2,4'-imidazolidine]-2',5'-dithione 

Relevant articles and documents

Unexpected reactivity of diaryl α-diketones with thiazolium carbenes: Discovery of a novel multicomponent reaction for the facile synthesis of 1,4-thiazin-3-ones

Diaryl α-diketones do not undergo polarity reversal in the presence of (benzo)thiazolium carbenes but are engaged in a novel multicomponent reaction with water to efficiently give medicinally relevant 1,4-thiazin-3-one heterocycles. Three different sets of conditions have been optimized to furnish the title compounds in fair to excellent yields depending on the electronic properties of α-diketone aromatic substituents and thiazolium or benzothiazolium substrate. A plausible reaction mechanism is also proposed based on the isolation and characterization of the postulated key intermediate and isotopic labeling experiments.

Benzoin Condensation Reactions of 5-Membered Heterocyclic Compounds

Benzoin condensation reactions of 2-thiophenecarboxaldehydes and furfurals have been reexamined with catalysts such as potassium cyanide, cyanide-resin, and a thiazolium salt. 2-Thiophenecarboxaldehydes gave both thenoins and thenils while furfurals gave only furoins.Possible routes which might lead to formation of thenils were investigated.