163213-33-0Relevant academic research and scientific papers
Nonpeptide glycoprotein IIb/IIIa inhibitors. 13. Design and synthesis of an orally active pyrazolopiperazinone nonpeptide fibrinogen receptor antagonist
Askew,McIntyre,Hunt,Claremon,Baldwin,Anderson,Gould,Lynch,Chang,Cook,Lynch,Holahan,Sitko,Stranieri
, p. 1531 - 1536 (1997)
The synthesis and antiplatelet activity of a series of pyrazolopiperazinone nonpeptide fibrinogen receptor antagonists is reported. The sulfonamide analog 6 (L-734,115), significantly inhibited ex vivo platelet aggregation 24 h after oral administration at doses of 1.0 and 2.0 mg/kg to dogs and rhesus monkeys, respectively.
