Nonpeptide glycoprotein IIb/IIIa inhibitors. 13. Design and synthesis of an orally active pyrazolopiperazinone nonpeptide fibrinogen receptor antagonist

DOI: 10.1016/S0960-894X(97)00256-4

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 1531 - 1536 (1997)

Update date:2022-08-02

Topics:

Authors:

Askew Askew

McIntyre

Hunt Hunt

Claremon

Baldwin Baldwin

Anderson

Gould Gould

Lynch Lynch

Chang Chang

Cook Cook

Lynch Lynch

Holahan Holahan

Sitko Sitko

Stranieri

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Article abstract of DOI:10.1016/S0960-894X(97)00256-4

The synthesis and antiplatelet activity of a series of pyrazolopiperazinone nonpeptide fibrinogen receptor antagonists is reported. The sulfonamide analog 6 (L-734,115), significantly inhibited ex vivo platelet aggregation 24 h after oral administration at doses of 1.0 and 2.0 mg/kg to dogs and rhesus monkeys, respectively.

Full text of DOI:10.1016/S0960-894X(97)00256-4

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