Bioorganic and Medicinal Chemistry Letters p. 1531 - 1536 (1997)
Update date:2022-08-02
Topics:
Askew
McIntyre
Hunt
Claremon
Baldwin
Anderson
Gould
Lynch
Chang
Cook
Lynch
Holahan
Sitko
Stranieri
The synthesis and antiplatelet activity of a series of pyrazolopiperazinone nonpeptide fibrinogen receptor antagonists is reported. The sulfonamide analog 6 (L-734,115), significantly inhibited ex vivo platelet aggregation 24 h after oral administration at doses of 1.0 and 2.0 mg/kg to dogs and rhesus monkeys, respectively.
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