1632198-74-3Relevant academic research and scientific papers
Highly efficient and stereoselective construction of bispirooxindole derivatives via a three-component 1,3-dipolar cycloaddition reaction
Xu, Qin,Wang, De,Wei, Yin,Shi, Min
, p. 93 - 98 (2014)
A highly regio- and stereoselective synthesis of bispirooxindoles by 1,3-dipolar cycloaddition of in situ generated azomethine ylides from isatin and proline to different electron-deficient alkenes has been developed. The synthesis affords the desired bispiro scaffold compounds in excellent yields with high regioselectivity under mild conditions. The stereochemistry was determined by single-crystal X-ray analysis.
