16331-48-9

Basic information

• Product Name: 4-ACETAMIDOBENZOYL CHLORIDE
• Synonyms: 4-ACETAMIDOBENZOYL CHLORIDE;4-(Acetylamino)benzoyl chloride
• CAS NO: 16331-48-9
• Molecular Formula: C₉H₈ClNO₂
• Molecular Weight: 197.62
• EINECS: -0
• Mol File: 16331-48-9.mol

Chemical Properties

• Melting Point: 180°C
• Boiling Point: 387.3°Cat760mmHg
• Flash Point: 188°C
• Appearance: /
• Density: 1.326g/cm³
• Vapor Pressure: 3.33E-06mmHg at 25°C
• Refractive Index: 1.597
• PKA: 14.46±0.70(Predicted)
• Sensitive: Moisture Sensitive
• CAS DataBase Reference: 4-ACETAMIDOBENZOYL CHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-ACETAMIDOBENZOYL CHLORIDE(16331-48-9)
• EPA Substance Registry System: 4-ACETAMIDOBENZOYL CHLORIDE(16331-48-9)

Safety Data

• Statements: 34
• Safety Statements: 26-36/37/39
• RIDADR: 3261
• HazardClass: 8
• PackingGroup: II
• Hazardous Substances Data: 16331-48-9(Hazardous Substances Data)

Usage

InChI:InChI=1/C9H8ClNO2/c1-6(12)11-8-4-2-7(3-5-8)9(10)13/h2-5H,1H3,(H,11,12)

Upstream product

• 556-08-1 p-(acetylamino)benzoic acid 
• 79-37-8 oxalyl dichloride 

Downstream Products

• 107621-91-0 4-acetylamino-benzoic acid-(2-methyl-4-oxo-4H-quinazolin-3-ylamide) 
• 42308-94-1 1-(4-acetylamino-benzoyl)-thiosemicarbazide 
• 1225463-00-2 4-acetamido-N-methoxybenzamide 
• 1246738-47-5 mutilin 14-O-[1-(4-acetamido)benzamide-2-methylpropane-2-yl]thioacetate 
• 10205-61-5 N-[4-(6-methyl-benzothiazol-2-yl)-phenyl]-acetamide 
• 110386-74-8 p-acetylaminobenzoyl-dimethylaminoethanthiol hydrochloride 
• 133041-88-0 N-<4'-phenyl>-1-acetamidobenzamide 
• 126916-61-8 4-Acetylamino-N-[(1S,2S)-2-(2,4-difluoro-phenyl)-2-hydroxy-1-methyl-3-[1,2,4]triazol-1-yl-propyl]-benzamide 
• 83231-45-2 4-Acetylamino-benzoic acid 2-hydroxy-3-isopropylamino-propyl ester 
• 6265-57-2 N-[4-(1,3-benzothiazol-2-yl)phenyl]acetamide 
• 99-92-3 p-aminobenzophenone 
• 106271-34-5 N-(4-acetylamino-benzoyl)-N'-(5-nitro-furan-2-carbonyl)-hydrazine 
• 106473-61-4 furan-2-carboxylic acid-[N'-(4-acetylamino-benzoyl)-hydrazide] 

Relevant articles and documents

Metabolites of a blocked chloramphenicol producer

Addition of p-aminophenylalanine (4), an advanced biosynthetic precursor of the antibiotic chloramphenicol (5), to a Streptomyces venezuelae pabAB mutant (VS629) restored chloramphenicol production and led to formation of the non-chlorinated analogue corynecin II (6) and four acetanilide derivatives: p-(acetylamino)phenylalanine (7), p-(acetylamino)benzyl alcohol (13), p-(acetylamino)benzoic acid (14), and p-(acetylamino)phenol (acetaminophen, 16). Metabolite structures were deduced from NMR and MS-MS data and established by chromatographic and spectroscopic comparisons with authentic samples. Reference compound 13 was synthesized by reducing the acid chloride of 14. Shunt pathways are proposed to account for the formation of the metabolites from p-aminophenylalanine.

Active group, preparation method and application thereof

The invention relates to a brand-new active group sulfonyl isothiocyanate, namely -SO2NCS. The sulfonyl isothiocyanate group (-SO2NCS) is introduced into the field of reactive dyes, and a dye intermediate synthesized through a chemical reaction is as shown in general formula (I) in the specification, but not limited to the following general formula (I), the structure shown as the general formula (I) is subjected to a chemical reaction to form a component of a dye molecule, so that the dye becomes a novel reactive dye, and the reactive dye has the advantages of simple synthesis process, mild dyeing conditions, difficult hydrolysis, excellent color fastness to washing, zero sewage discharge and the like. The problems of heavy pollution, easy hydrolysis, harsh dyeing conditions and the like of the current traditional reactive dye are solved.

Nickel-Catalyzed Deaminative Acylation of Activated Aliphatic Amines with Aromatic Amides via C-N Bond Activation

Deaminative functionalization of aliphatic primary amines has great synthetic utility. Herein, we describe a Ni-catalyzed reductive deaminative cross-electrophile coupling reaction between Katritzky salts and aromatic amides. This work provides examples of the synthesis of various ketones from alkylpyridinium salts, including both primary and secondary alkylamines. Given its mild reaction conditions and high functional group tolerance, this cross-coupling strategy is expected to be useful for late-stage functionalization of complex compounds.

Cu-Catalyzed C-H Alkenylation of Benzoic Acid and Acrylic Acid Derivatives with Vinyl Boronates

An efficient Cu-catalyzed C-H alkenylation with acyclic and cyclic vinyl boronates was realized for the first time under mild conditions. The scope of the vinyl borons and the compatibility with functional groups including heterocycles are superior than Pd-catalyzed C-H coupling with vinyl borons, providing a reliable access to multisubstituted alkenes and dienes. Subsequent hydrogenation of the product from the internal vinyl borons will lead to installation of secondary alkyls.

Active-methylene azo-type reactive dye and preparation method thereof

The invention relates to the technical field of organic synthesis, in particular to an active-methylene azo-type reactive dye and a preparation method thereof. The active-methylene azo-type reactive dye is of a structure of a general formula (I) or (II) (the formula is shown in the description). The dye is obtained by coupling an active-methylene-containing compound and a derivative thereof with aspecific reactive group. The -COF reactive group is introduced into the compound through a coupling reaction, and the hydrophilicity of the obtained compound can be improved through an acyl fluoridegroup; meanwhile, the density of an electron cloud of a color development matrix in the molecular structure of the compound can be effectively reduced through the strong electron attracting effect ofthe -COF, the light stability of the dye on base materials such as various fabrics can be improved, and the light fastness can be improved.

A compound and its preparation method, use (by machine translation)

The present invention provides a compound and its preparation method, use. A compound, having the general formula (I) of the structure: Wherein R1 , R2 , R3 , R4 And R5 In at least one is a amino, the remaining are independently selected from H, halogen, heteroatom substituted or not substituted C1 - 20 Hydrocarbyl. The compound having an active group - COF, easy and cellulose surface active groups (hydroxyl, amino) reaction, and itself is not easy to hydrolyze, therefore made of azo dye in water and it has strong stability, and the dyeing ability. (by machine translation)

Aminonaphthol sulfonic acid azo reactive dye and preparing method thereof

The invention relates to the technical field of organic synthesis, in particular to an aminonaphthol sulfonic acid azo reactive dye and a preparing method thereof. The structure of the aminonaphthol sulfonic acid azo reactive dye is shown in a general formula (I), general formula (II) or general formula (III), wherein X represents at least one sulfonic acid group of R1, R2, R3, R4 and R5, one of Y1 and Y2 is selected from a hydroxy group, and the other one of Y1 and Y2 is selected from amidogen. According to the aminonaphthol sulfonic acid azo reactive dye, by cooperating aminonaphthol sulfonic acid and derivatives thereof with active groups, compounds containing azo structures are prepared, and by introducing -COF active groups, the electron cloud density of a dye parent can be reduced; the photostability of the dye on fibers is improved, and the lightfastness of the dye is improved.

Phenolic azo type reactive dye and preparation method thereof

The invention provides a phenolic azo type reactive dye and a preparation method thereof. The phenolic azo type reactive dye has structures of the general formula (I), (II) or (III).A preparation process of the above phenolic azo type reactive dye comprises the steps that after a diazotization reaction,a coupling reaction is carried out to obtain the dye (I), (II) or (III). The dye has good leveling property and has good light fastness and washing fastness.

Direct allylation of aromatic and α,β-unsaturated carboxamides under ruthenium catalysis

The ruthenium-catalyzed oxidative allylation of aromatic and α,β-unsaturated carboxamides with allylic carbonates is described. These transformations proceed readily with complete linear γ-selectivity of substituted allylic carbonates. the Partner Organisations 2014.

NOVEL BICYCLIC THIAZOLE COMPOUNDS

The present invention relates to novel bicyclic thiazole compounds that inhibit Traf2- and Nck-interacting kinase (TNIK), and as such are useful as TNIK inhibitors administered to cancer patients, especially to solid cancer patients such as colorectal cancer, pancreatic cancer, non-small cell lung cancer, prostate cancer or breast cancer. The bicyclic thiazole compounds are showed by a next formula (I). (wherein R1, R2, R3 and Q are as defined in the specification), or a pharmaceutically acceptable salt thereof.