16331-48-9

Basic information

• Product Name: 4-ACETAMIDOBENZOYL CHLORIDE
• Synonyms: 4-ACETAMIDOBENZOYL CHLORIDE;4-(Acetylamino)benzoyl chloride
• CAS NO: 16331-48-9
• Molecular Formula: C₉H₈ClNO₂
• Molecular Weight: 197.62
• EINECS: -0
• Mol File: 16331-48-9.mol
• Article Data: 19

Chemical Properties

• Melting Point: 180°C
• Boiling Point: 387.3°Cat760mmHg
• Flash Point: 188°C
• Appearance: /
• Density: 1.326g/cm³
• Vapor Pressure: 3.33E-06mmHg at 25°C
• Refractive Index: 1.597
• PKA: 14.46±0.70(Predicted)
• Sensitive: Moisture Sensitive
• CAS DataBase Reference: 4-ACETAMIDOBENZOYL CHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-ACETAMIDOBENZOYL CHLORIDE(16331-48-9)
• EPA Substance Registry System: 4-ACETAMIDOBENZOYL CHLORIDE(16331-48-9)

Safety Data

• Statements: 34
• Safety Statements: 26-36/37/39
• RIDADR: 3261
• HazardClass: 8
• PackingGroup: II
• Hazardous Substances Data: 16331-48-9(Hazardous Substances Data)

Usage

InChI:InChI=1/C9H8ClNO2/c1-6(12)11-8-4-2-7(3-5-8)9(10)13/h2-5H,1H3,(H,11,12)

Upstream product

• 79-37-8 oxalyl dichloride 
• 556-08-1 p-(acetylamino)benzoic acid 

Downstream Products

• 99-92-3 p-aminobenzophenone 
• 10205-61-5 N-[4-(6-methyl-benzothiazol-2-yl)-phenyl]-acetamide 
• 1025061-08-8 C₁₇H₁₆N₆O₉ 
• 1111287-26-3 4-acetamido-N-(4-methyl-2-oxo-2H-chromen-7-yl)benzamide 
• 1155877-78-3 N-[4-(3'-Bromo-2-fluoro-6-methoxy-biphenyl-3-carbonyl)-phenyl]-acetamide 
• 1446481-84-0 C₂₁H₂₂BF₂N₃O 
• 1446481-95-3 di-μ-tosyloxybis(4-methoxy-2-acetaminophenyl-2C,O)dipalladium(II) 
• 16375-88-5 N-(4-hydroxymethylphenyl)acetamide 
• 179384-48-6 [5-(4-acetylamino-benzoyl)-1-methyl-1H-pyrrol-2-yl]-acetic acid methyl ester 
• 110386-74-8 p-acetylaminobenzoyl-dimethylaminoethanthiol hydrochloride 

Relevant articles and documents

Metabolites of a blocked chloramphenicol producer

Addition of p-aminophenylalanine (4), an advanced biosynthetic precursor of the antibiotic chloramphenicol (5), to a Streptomyces venezuelae pabAB mutant (VS629) restored chloramphenicol production and led to formation of the non-chlorinated analogue corynecin II (6) and four acetanilide derivatives: p-(acetylamino)phenylalanine (7), p-(acetylamino)benzyl alcohol (13), p-(acetylamino)benzoic acid (14), and p-(acetylamino)phenol (acetaminophen, 16). Metabolite structures were deduced from NMR and MS-MS data and established by chromatographic and spectroscopic comparisons with authentic samples. Reference compound 13 was synthesized by reducing the acid chloride of 14. Shunt pathways are proposed to account for the formation of the metabolites from p-aminophenylalanine.

Nickel-Catalyzed Deaminative Acylation of Activated Aliphatic Amines with Aromatic Amides via C-N Bond Activation

Deaminative functionalization of aliphatic primary amines has great synthetic utility. Herein, we describe a Ni-catalyzed reductive deaminative cross-electrophile coupling reaction between Katritzky salts and aromatic amides. This work provides examples of the synthesis of various ketones from alkylpyridinium salts, including both primary and secondary alkylamines. Given its mild reaction conditions and high functional group tolerance, this cross-coupling strategy is expected to be useful for late-stage functionalization of complex compounds.

Active-methylene azo-type reactive dye and preparation method thereof

The invention relates to the technical field of organic synthesis, in particular to an active-methylene azo-type reactive dye and a preparation method thereof. The active-methylene azo-type reactive dye is of a structure of a general formula (I) or (II) (the formula is shown in the description). The dye is obtained by coupling an active-methylene-containing compound and a derivative thereof with aspecific reactive group. The -COF reactive group is introduced into the compound through a coupling reaction, and the hydrophilicity of the obtained compound can be improved through an acyl fluoridegroup; meanwhile, the density of an electron cloud of a color development matrix in the molecular structure of the compound can be effectively reduced through the strong electron attracting effect ofthe -COF, the light stability of the dye on base materials such as various fabrics can be improved, and the light fastness can be improved.