16341-54-1

Basic information

• Product Name: 5-Pyrimidinecarbonitrile, 2-amino-4,6-dimethyl- (8CI,9CI)
• Synonyms: 5-Pyrimidinecarbonitrile, 2-amino-4,6-dimethyl- (8CI,9CI);2-Amino-4,6-dimethylpyrimidine-5-carbonitrile;2-amino-4,6-dimethyl-5-pyrimidinecarbonitrile;5-Pyrimidinecarbonitrile,2-amino-4,6-dimethyl-
• CAS NO: 16341-54-1
• Molecular Formula: C₇H₈N₄
• Molecular Weight: 148.16522
• Product Categories: PYRIMIDINE
• Mol File: 16341-54-1.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 5-Pyrimidinecarbonitrile, 2-amino-4,6-dimethyl- (8CI,9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Pyrimidinecarbonitrile, 2-amino-4,6-dimethyl- (8CI,9CI)(16341-54-1)
• EPA Substance Registry System: 5-Pyrimidinecarbonitrile, 2-amino-4,6-dimethyl- (8CI,9CI)(16341-54-1)

Safety Data

• Hazardous Substances Data: 16341-54-1(Hazardous Substances Data)

Upstream product

• 4214-57-7 2-amino-5-bromo-4,6-dimethylpyrimidine 
• 544-92-3 copper(I) cyanide 
• 113-00-8 guanidine nitrate 
• 6081-80-7 2-acetyl-3-phenylamino-2-butenenitrile 
• 108086-95-9 2-acetyl-3-methylamino-2-butenenitrile 

Downstream Products

• 369384-16-7 2-tert-butoxycarbonylimino-4,6-dimethyl-5-{[2-(6-methyl-2-oxo-3-phenylmethanesulfonylamino-2H-pyridin-1-yl)-acetylamino]-methyl}-2H-pyrimidine-1-carboxylic acid tert-butyl ester 

Relevant articles and documents

SUBSTITUTED NITROGEN CONTAINING COMPOUNDS

Disclosed are compounds of Formula (I): or a salt thereof, Formula (II) wherein R1 is: or; each W is independently NR1b or O; Z is a bond or CHR1d; and R1, R2, Rd, R3a, R3b, L1, B, V, Y, and n are defined herein. Also disclosed are methods of using such compounds as inhibitors of ROMK, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating cardiovascular diseases.

Non-covalent thrombin inhibitors featuring P3-heterocycles with P1-monocyclic arginine surrogates

Investigations on P2-P3-heterocyclic dipeptide surrogates directed towards identification of an orally bioavailable thrombin inhibitor led us to pursue novel classes of achiral, non-covalent P1-arginine derivatives. The design, synthesis, and biological activity of inhibitors NC1-NC30 that feature three classes of monocyclic P1-arginine surrogates will be disclosed: (1) (hetero)aromatic amidines, amines and hydroxyamidines, (2) 2-aminopyrazines, and (3) 2-aminopyrimidines and 2-aminotetrahydropyrimidines.