163457-29-2

Upstream product

• 163457-33-8 (R)-2-(tert-Butyl-dimethyl-silanyloxymethyl)-butyric acid 
• 163457-34-9 (+)-(4S)-3-<(2'R)-2'-((benzyloxy)methyl)butanoyl>-4-benzyl-2-oxazolidinone 
• 163457-37-2 (-)-p-fluorophenyl (2E)-4-<((2'R)-2'-((tert-butyldimethylsiloxy)methyl)butanoyl)oxy>-2-butenoate 
• 173423-74-0 (E)-4-(tert-Butyl-dimethyl-silanyloxy)-but-2-enoic acid 4-fluoro-phenyl ester 
• 157405-12-4 (+)-(4S)-3-<(2'R)-2'-((tert-Butyldimethylsiloxy)methyl)butanoyl>-4-benzyl-2-oxazolidinone 
• 150615-45-5 (+)-(4S)-3-<(2'R)-2'-(hydroxymethyl)butanoyl>-4-benzyl-2-oxazolidinone 
• 163457-38-3 (E)-4-((R)-2-Hydroxymethyl-butyryloxy)-but-2-enoic acid 4-fluoro-phenyl ester 
• 163457-40-7 p-fluorophenyl (2E)-4-hydroxy-2-butenoate 
• 371-41-5 4-Fluorophenol 

Relevant academic research and scientific papers

Synthesis of six-membered compounds by environmentally friendly cyclization using indirect electrolysis

[Ni(cyclam)](ClO4)2-catalyzed indirect electroreduction of olefinic bromides produced six-membered compounds in low to high yields. The synthetic intermediate 49 of Ipecac and Corynanthe alkaloids was obtained in 88% yield in a highly stereoselective manner. Lactam 66, the synthetic precursor of tacamonine, was prepared in 49% yield as a mixture of two diastereoisomers. The electrolysis of the bromoacetates gave the debrominated compounds in good yields.

Indirect electroreductive cyclization for syntheses of key intermediates of several indole and ipecac alkaloids

Indirect electroreductive cyclization of η-bromo-α,β-unsaturated esters 1-6 using Co(III) or Ni(II) complex as an electron-transfer catalyst provided the six membered compounds 7-12, which are useful synthetic intermediates of several indole and ipecac al