Asymmetric synthesis of trans-2,5-diphenylpyrrolidine: A C2-symmetric chiral amine

DOI: 10.1016/0957-4166(95)00026-L

Source and publish data:

Tetrahedron Asymmetry p. 409 - 418 (1995)

Update date:2022-08-02

Topics:

Authors:

Chong Chong

Clarke Clarke

Koch Koch

Olbach Olbach

Taylor Taylor

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Article abstract of DOI:10.1016/0957-4166(95)00026-L

(R,R)-2,5-Diphenylpyrrolidine of high enantiomeric purity (>98% e.e.) may be prepared from 1,4-diphenyl-1,4-butanedione in 4 steps and 64% overall yield. A key step is asymmetric reduction of the dione with Ipc₂BCl.

Full text of DOI:10.1016/0957-4166(95)00026-L

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Product name:(1S,4S)-1,4-diphenyl-1,4-butanediol bis(methanesulfonic acid ester)

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