163631-85-4

Basic information

• Product Name: N⁶-(1-nitropyren-6-yl)-3'-O-(tetrahydrofuranyl)-5'-O-trityldeoxyadenosine
• Synonyms: N⁶-(1-nitropyren-6-yl)-3'-O-(tetrahydrofuranyl)-5'-O-trityldeoxyadenosine
• CAS NO: 163631-85-4
• Molecular Weight: 808.893
• Mol File: 163631-85-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N⁶-(1-nitropyren-6-yl)-3'-O-(tetrahydrofuranyl)-5'-O-trityldeoxyadenosine(CAS DataBase Reference)
• NIST Chemistry Reference: N⁶-(1-nitropyren-6-yl)-3'-O-(tetrahydrofuranyl)-5'-O-trityldeoxyadenosine(163631-85-4)
• EPA Substance Registry System: N⁶-(1-nitropyren-6-yl)-3'-O-(tetrahydrofuranyl)-5'-O-trityldeoxyadenosine(163631-85-4)

Safety Data

• Hazardous Substances Data: 163631-85-4(Hazardous Substances Data)

Upstream product

• 1691-65-2 1-fluoropyrene 
• 1606-67-3 1-aminopyrene 
• 163631-82-1 6-fluoro-1-nitropyrene 

Relevant articles and documents

Synthesis of N-(1-nitropyren-6-yl and 8-yl)-2'-deoxyribonucleosides

A new type of 1-nitropyrene-DNA adduct via addition-elimination reaction was synthesized. Treatment of fluorinated 1-nitropyrene with 3'- and 5'-O- protected 2'-deoxyribonucleoside in dimethyl sulfoxide at 140 °C afforded N- (1-nitropyren-6-yl or 8-yl)-2'-deoxyribonucleoside. These DNA adducts resulted from addition of the exocyclic amino group of deoxynucleosides to the fluorinated carbon of the fluoro-1-nitropyrene following elimination of fluoride anion. This is the first report that describes the 1-nitropyrene- DNA adducts in which aromatic ring moiety of 1-nitropyrene is covalently linked to the exocyclic amino group of the deoxyribonucleoside. From our findings, we suggest that the addition-elimination reaction may be responsible for the formation mechanism of the putative 1-nitropyrene-DNA adducts in vivo.