16367-94-5

Upstream product

• 95-54-5 1,2-diamino-benzene 
• 500857-82-9 3,3-dichloro-1-methyl-1,3-dihydro-2,1-benzisothiazole 2,2-dioxide 
• 24827-66-5 1-methyl-1,3-dihydrobenzo[c]isothiazole-2,2-dioxide 
• 13275-42-8 2-(2-bromophenyl)-benzimidazole 
• 74-89-5 methylamine 
• 5805-39-0 2-(aminophenyl)benzimidazole 
• 118-92-3 anthranilic acid 

Relevant academic research and scientific papers

Reactions of 6-(dichloromethylene)cyclohexa-2,4-dien-1-alkylimines with amines

Chlorination of 2,1-benzisothiazoline 2,2-dioxides (benzosultams) with hexachloroethane under phase-transfer catalysis condition in the presence of 50% aqueous NaOH and tetraalkylammonium salt gives 3,3-dichlorobenzosultams in good yields. Thermal extrusion of SO2 from 3,3-dichloropyridosultams generates dichloro derivatives of aza-ortho-xylylenes which do not enter [4+2] cycloaddition reactions, but add amines to form amidines. With aromatic diamines and aminophenols, benzimidazole and benzoxazole derivatives are formed in good yields.

Synthesis, antimicrobial, and mitotic toxicity evaluation of new 6-substituted 2-(benzo[4,5]imidazo[1,2-c]quinazolin-5(6H)-yl)acetic acids

A series of novel 6-substituted 2-(benzo[4,5]imidazo[1,2-c]quinazolin-5(6H)-yl)acetic acids were synthesized and characterized by 1H, 13C, 19F NMR, 1H-1H-COSY, 1H-13C-HSQC, NOESY, LC-MS, IR, and elemental analysis. The mitotic toxicity of the synthesized compounds was determined according to the Allium test procedure. The 2-(6-(pentafluorophenyl)benzo[4,5]imidazo[1,2-c]quinazolin-5(6H)-yl)acetic acid inhibited mitotic spindle formation, which resulted in significant cytotoxic effect for meristematic cells of Allium cepa l. roots. In a preliminary antimicrobial evaluation, only Streptococcus pyogenes and Candida albicans were slightly susceptible to some of the synthesized compounds.

Copper-catalyzed cascade synthesis of benzimidazoquinazoline derivatives under mild condition

A convenient and efficient copper-catalyzed cascade method has been developed for the synthesis of benzimidazoquinazoline derivatives via reactions of readily available substituted 2-(2-halophenyl)benzoimidazoles with amidines or guanidine under mild conditions (even at room temperature).