163734-89-2

Usage

Molecular Structure

1H-Indole-3-acetic acid, 2-bromo-5-methoxy-1-(phenylmethyl)-, phenylmethyl ester is a chemical compound with a modified indole-3-acetic acid structure, which includes a bromine atom, a methoxy group, and a phenylmethyl ester.

Derivative of Hormone

It is a derivative of the hormone indole-3-acetic acid, which is involved in plant growth and development.

Modification of Chemical Structure

The addition of a bromine and methoxy group, as well as a phenylmethyl ester, modifies the chemical structure and potentially enhances its biological activity.

Increased Lipophilicity

The presence of the phenylmethyl ester increases the compound's lipophilicity, which may improve its cellular uptake and distribution.

Potential Pharmaceutical Applications

1H-Indole-3-acetic acid, 2-bromo-5-methoxy-1-(phenylmethyl)-, phenylmethyl ester may have potential applications in the field of medicine due to its modified structure and enhanced biological activity.

Potential Agricultural Applications

It may also have potential applications in agriculture, particularly in the development of new crop improvement strategies, as it is derived from a hormone involved in plant growth and development.

Upstream product

• 185064-27-1 5-methoxy-1-(phenylmethyl)-1H-indole-3-acetic acid phenylmethyl ester 
• 3471-31-6 5-methoxy-1H-indole-3-acetic acid 
• 100-39-0 benzyl bromide 
• 128-08-5 N-Bromosuccinimide 

Downstream Products

• 164083-06-1 2-bromo-5-methoxy-1-(phenylmethyl)-1H-indole-3-acetamide 

Relevant academic research and scientific papers

1H-INDOLE-3-ACETAMIDE SPLA2 INHIBITORS

A class of novel 1-indole-3-acetamides represented by the formula; is disclosed together with the use of such indole compounds for inhibiting sPLA2 mediated release of fatty acids.

Indole inhibitors of human nonpancreatic secretory phospholipase A2. 1. Indole-3-acetamides

Phospholipases (PLAs) produce rate-limiting precursors in the biosynthesis of various types of biologically active lipids involved in inflammatory processes. Increased levels of human nonpancreatic secretory phospholipase A2 (hnps-PLA2) have been detected in several pathological conditions. An inhibitor of this enzyme could have therapeutic utility. A broad screening program was carried out to identify chemical structures which could inhibit hnps-PLA2. One of the lead compounds generated by the screening program was 5-methoxy-2-methyl-1-(phenylmethyl)-1H-indole-3-acetic acid (13a). We describe the syntheses, structure-activity relationships, and pharmacological activities of a series of indole-3-acetamides and related compounds derived from this lead. This SAR was undertaken with the aid of X- ray crystal structures of complexes between the inhibitors and hnps-PLA2 which were of great value in directing the SAR.

1H-INDOLE-3-ACETIC ACID HYDRAZIDE SPLA2 INHIBITORS

A class of novel 1H-indole-3-acetic acid hydrazides is disclosed together with the use of such indole compounds for inhibiting sPLA2 mediated release of fatty acids (e.g., arachidonic acid) for treatment of conditions such as septic shock