1637489-71-4Relevant academic research and scientific papers
Synthesis of 1-(Cyclohexylamino)-2-(aryl)pyrrolo[1,2-a]quinoline-3- carbonitrile Derivatives Using a Mild, Four-Component Reaction
Maghsoodlou, Malek Taher,Hazeri, Nourallah,Khandan-Barani, Khatereh,Habibi-Khorasani, Sayyed Mostafa,Abedi, Alireza
, p. E152-E155 (2014)
1-(Cyclohexylamino)-2-(aryl)pyrrolo[1,2-a]quinoline-3-carbonitrile derivatives were synthesized in an efficient method from four-component condensation reaction between cyclohexyl isocyanide, quinoline, malononitrile, and aromatic aldehydes in the presence of a catalytic amount of titanium dioxide (TiO2) in CH2Cl2 at ambient temperature in good yields. Silica gel column chromatography was employed for HCN elimination and then 1, 3 hydrogen shift was led to form final products 5a, 5b, 5c, 5d, 5e.
A one-pot four-component synthesis of pyrrolo[1,2-a]quinolines
Adib, Mehdi,Azimzadeh, Marjan,Rahimi-Nasrabadi, Mehdi,Zhu, Long-Guan
, p. 423 - 426 (2014/08/05)
A facile one-pot, four-component reaction for the synthesis of pyrrolo[1,2-a]quinolines is described. Knoevenagel condensation reaction of malononitrile and aromatic aldehydes gave 2-arylmethylidenemalononitriles which on treatment with quinoline and cycl
