1637593-18-0

Basic information

• Product Name: 3-(4-(3-chloropropoxy)-5-methoxy-2-nitrophenyl)-3-oxopropanenitrile
• Synonyms: 3-(4-(3-chloropropoxy)-5-methoxy-2-nitrophenyl)-3-oxopropanenitrile
• CAS NO: 1637593-18-0
• Molecular Weight: 312.71
• Mol File: 1637593-18-0.mol

Chemical Properties

• CAS DataBase Reference: 3-(4-(3-chloropropoxy)-5-methoxy-2-nitrophenyl)-3-oxopropanenitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-(3-chloropropoxy)-5-methoxy-2-nitrophenyl)-3-oxopropanenitrile(1637593-18-0)
• EPA Substance Registry System: 3-(4-(3-chloropropoxy)-5-methoxy-2-nitrophenyl)-3-oxopropanenitrile(1637593-18-0)

Safety Data

• Hazardous Substances Data: 1637593-18-0(Hazardous Substances Data)

Upstream product

• 1637593-16-8 4-(3-chloropropoxy)-5-methoxy-2-nitrobenzoyl chloride 
• 111627-40-8 methyl 4-(3-chloropropoxy)-3-methoxybenzoate 
• 151719-68-5 4-(3-Chloropropoxy]-3-methoxybenzoic acid 
• 1637593-17-9 ethyl 3-(4-(3-chloropropoxy)-5-methoxy-2-nitrophenyl)-2-cyano-3-oxopropanoate 
• 3943-74-6 4-hydroxy-3-methoxybenzoic acid methyl ester 
• 214470-57-2 methyl 4-(3-chloropropoxy)-5-methoxy-2-nitrobenzoate 
• 498-02-2 1-(3-methoxy-4-hydroxyphenyl)ethanone 
• 58113-30-7 4-(3-chloropropoxy)-3-methoxyacetophenone 
• 1160707-44-7 1-[4-(3-chloropropoxy)-5-methoxy-2-nitrophenyl]ethan-1-one 
• 773837-37-9 sodium cyanide 

Downstream Products

• 1637593-19-1 3-(2-amino-4-(3-chloropropoxy)-5-methoxyphenyl)-3-oxopropanenitrile 
• 214470-66-3 7-(3-chloropropoxy)-6-methoxy-4-oxo-1,4-dihydroquinoline-3-carbonitrile 
• 380843-75-4 bosutinib 
• 214470-68-5 7-(3-chloro-propoxy)-4-chloro-6-methoxy-quinoline-3-carbonitrile 
• 380844-49-5 7-(3-chloropropoxy)-4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-3-quinolinecarbonitrile 

Relevant articles and documents

New Synthetic Process for Bosutinib

A new and improved synthetic route to bosutinib is described on a hectogram scale. The key step is the intramolecular cyclization of a 3-(2-aminophenyl)-3-oxopropanenitrile with N,N-dimethylformamide dimethyl acetal to form the 3-cyano-4-hydroxyquinoline ring of 7-(3-chloropropoxy)-6-methoxy-4-oxo-1,4-dihydroquinoline-3-carbonitrile. A practical synthetic method to 2,4-dichloro-5-methoxyaniline is also established. Bosutinib is obtained in 18.0% yield over nine steps from acetovanillone with 98.9% purity (HPLC).

A new and practical synthesis of 7-(3-chloropropoxy)-6-methoxy-4-oxo-1,4-dihydroquinoline-3-carbonitrile

New and improved synthetic route of bosutinib intermediate 7-(3-chloropropoxy)-6-methoxy-4-oxo-1,4-dihydroquinoline-3-carbonitrile (3) is described on a hectogram scale. An intramolecular cyclization of 3-(2-aminophenyl)-3-oxopropanenitrile 11 with DMF-DM