214470-57-2

Basic information

• Product Name: Methyl 4-(3-chloropropoxy)-5-Methoxy-2-nitrobenzoate
• Synonyms: Methyl 4-(3-chloropropoxy)-5-Methoxy-2-nitrobenzoate;4-(3-chloropropoxy)-5-Methoxy-2-nitrobenzoate;2-Nitro-4-(3-chloro-propoxy)-5-methoxy-benzoic acid methyl ester
• CAS NO: 214470-57-2
• Molecular Formula: C₁₂H₁₄ClNO₆
• Molecular Weight: 303.69566
• Mol File: 214470-57-2.mol
• Article Data: 35

Chemical Properties

• Melting Point: 54-56 °C(Solv: ethyl acetate (141-78-6); ligroine (8032-32-4))
• Boiling Point: 457.3±40.0 °C(Predicted)
• Appearance: /
• Density: 1.311±0.06 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: Methyl 4-(3-chloropropoxy)-5-Methoxy-2-nitrobenzoate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl 4-(3-chloropropoxy)-5-Methoxy-2-nitrobenzoate(214470-57-2)
• EPA Substance Registry System: Methyl 4-(3-chloropropoxy)-5-Methoxy-2-nitrobenzoate(214470-57-2)

Safety Data

• Hazardous Substances Data: 214470-57-2(Hazardous Substances Data)

Usage

General Description

Methyl 4-(3-chloropropoxy)-5-methoxy-2-nitrobenzoate is a chemical compound with the chemical formula C12H13ClNO6. It is a benzoate ester that contains a nitro group, a methoxy group, and a chloropropoxy group. Methyl 4-(3-chloropropoxy)-5-Methoxy-2-nitrobenzoate is often used in organic synthesis and medicinal chemistry. It may be used as a precursor in the synthesis of pharmaceuticals or as a reagent in chemical reactions. It is important to handle this compound with care, as it may be hazardous if not used properly.

Upstream product

• 6702-50-7 3-hydroxy-4-methoxybenzoate 
• 121-34-6 3-methoxy-4-hydroxybenzoic acid 
• 3943-74-6 4-hydroxy-3-methoxybenzoic acid methyl ester 
• 6940-76-7 1-iodo-3-chloro-propane 
• 111627-40-8 methyl 4-(3-chloropropoxy)-3-methoxybenzoate 

Downstream Products

• 927173-22-6 methyl 5-methoxy-2-nitro-4-(3-(piperidin-1-yl)propoxy)benzoate 
• 1188907-05-2 1-(5-tert-butyl-isoxazol-3-yl)-3-{3-[7-(3-chloro-propoxy)-6-methoxy-quinazolin-4-yloxy]-phenyl}-urea 
• 1188907-04-1 1-(5-tert-butylisoxazol-3-yl)-3-(3-(6-methoxy-7-(3-morpholinopropoxy)quinazolin-4-yloxy)phenyl)urea 
• 1481677-78-4 UNC0642 
• 1227263-96-8 N-mesityl-2-(6-methoxy-7-(3-(2-methylpiperidin-1-yl)propoxy)quinazolin-4-ylamino)benzo[d]thiazole-6-carboxamide 
• 1227263-95-7 N-mesityl-2-(6-methoxy-7-(3-morpholinopropoxy)quinazolin-4-ylamino)benzo[d]thiazole-6-carboxamide 
• 1227263-94-6 N-mesityl-2-(6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinazolin-4-ylamino)benzo[d]thiazole-6-carboxamide 
• 1227263-93-5 2-(7-(3-(diethylamino)propoxy)-6-methoxyquinazolin-4-ylamino)-N-mesitylbenzo[d]thiazole-6-carboxamide 
• 1227263-92-4 N-mesityl-2-(6-methoxy-7-(3-(piperidin-1-yl)propoxy)quinazolin-4-ylamino)benzo[d]thiazole-6-carboxamide 

Relevant articles and documents

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Several novel quinazolino [3, 4-a] thieno [3, 2-d] pyrimidin-8-one derivatives were synthesized. All of the compounds were determined against MiaPaCa2 and DU145 cells in vitro, and the crystal structures of analog 8 and 20 in the active site of the EGFR c

Design, synthesis, evaluation and molecular modeling study of 4-N-phenylaminoquinolines for Alzheimer disease treatment

Dual binding site acetylcholinesterase (AChE) inhibitors and butyrylcholinesterase (BChE) inhibitors have recently emerged as two classes of new anti-Alzheimer agents to positively modify the disease's course. In this work, a new series of 4-N-phenylaminoquinolines was synthesized and evaluated for their abilities to inhibit AChE and BChE. Compound 11b showed significant inhibitory activities on AChE and BChE with IC50 values of 0.86 and 2.65 μM, respectively, a lot better than that of reference drug galanthamine. Furthermore, docking study showed that compound 11b interacted simultaneously not only with active and peripheral sites of AChE, but also with all five regions of BChE active site. These findings suggest that these derivatives could be regarded as promising starting points for further drug discovery developments.

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