163769-88-8 Usage
Description
YM-90709 is a competitive antagonist of the interleukin-5 (IL-5) receptor that has IC50 values of 1 and 0.57 μM for peripheral human eosinophils and eosinophilic HL-60 clone 15 cells, respectively, in a radioligand binding assay. It inhibits IL-5-induced eosinophil survival (IC50 = 0.45 μM) and JAK2 phosphorylation in vitro. YM-90709 inhibits eosinophil and lymphocyte infiltration (ED50s = 0.32 and 0.12 mg/kg, respectively) into the brochoalveolar lavage fluid (BALF) of rats and eosinophil infiltration (ED50 = 0.05 mg/kg) into the BALF of mice in models of airway inflammation.
Uses
YM 90709, is an interleukin-5 receptor antagonist.
Biological Activity
Novel, selective inhibitor of interleukin-5 (IL-5) binding to its receptor (IC 50 = 0.45-1 mM). Inhibits IL-5-prolonged eosinophil survival and IL-5-induced tyrosine phosphorylation of JAK2 without inhibiting GM-CSF-mediated effects. In vivo, inhibits antigen-induced eosinophil and lymphocyte recruitment in rat airways, without affecting peripheral blood or bone marrow leukocytes.
Check Digit Verification of cas no
The CAS Registry Mumber 163769-88-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,6,3,7,6 and 9 respectively; the second part has 2 digits, 8 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 163769-88:
(8*1)+(7*6)+(6*3)+(5*7)+(4*6)+(3*9)+(2*8)+(1*8)=178
178 % 10 = 8
So 163769-88-8 is a valid CAS Registry Number.
InChI:InChI=1/C22H21N3O2/c1-22(2)12-13-9-19(26-3)20(27-4)10-14(13)18-11-17-21(25(18)22)24-16-8-6-5-7-15(16)23-17/h5-11H,12H2,1-4H3
163769-88-8Relevant articles and documents
REACTION OF ENAMINES OF THE ISOCHOLINE AND PHENANTHRIDINE SERIES WITH OXALYL CHLORIDE
Mikhailovskii, A.G.,Shklyeav, V.S.
, p. 818 - 821 (2007/10/02)
Compounds of the 2,3-dioxopyrroloisoquinoline and 2,3-dioxopyrrolophenanthridine series were synthesized and the products of their codensation with o-phenylenediamine were obtained.
