16382-10-8

Upstream product

• 89693-79-8 N-Nitroso-p-methylanilin 
• 617-35-6 2-oxo-propionic acid ethyl ester 
• 637-60-5 p-tolylhydrazine hydrochloride 
• 106-49-0 p-toluidine 
• 539-44-6 N-4-methylphenylhydrazine 
• 609-14-3 2-acetylpropanoic acid ethyl ester 
• 459-44-9 4-methylbenzenediazonium tetrafluoroborate 

Downstream Products

• 1159691-72-1 4-formyl-1-(4-methylphenyl)-1H-pyrazole-3-carboxylic acid 
• 1049130-57-5 2-(4-methylphenyl)-2,6-dihydro-7H-pyrazolo[3,4-d]pyridazin-7-one 
• 1159691-35-6 ethyl 4-formyl-1-(4-methylphenyl)-1H-pyrazole-3-carboxylate 
• 16382-15-3 5-methyl-1H-indole-2-carboxylic acid ethyl ester 
• 63514-80-7 ethyl 4-acetyl-5-methyl-1-(p-tolyl)-1H-pyrazole-3-carboxylate 

Relevant academic research and scientific papers

TOLL-LIKE RECEPTOR ANTAGONIST COMPOUNDS AND METHODS OF USE

The invention relates to compounds of formula (I): or a salt or solvate thereof, wherein the variables are as described herein. Compounds of formula (I) and pharmaceutical compositions thereof are antagonists of toll-like receptors such as TLR7, TLR8 and/or TLR9 that are useful for inhibiting immune response and treating diseases associated with undesirable immune response.

A new class of efficient 4-[(nitro substituted-phenyl)-hydrazonomethyl]-1-phenyl-1H-pyrazole-3-carboxylate derived colorimetric chemosensor for selective sensing of fluoride and other biologically important anions

A new class of efficient colorimetric chemosensors derived from 4-[(nitro substituted-phenyl)-hydrazonomethyl]-1-phenyl-1H-pyrazole-3-carboxylate have been synthesized and characterized. The synthesized receptors exhibit instant color change from yellow t

Rh(II)-catalyzed intramolecular annulation of N-sulfonyl 1,2,3-triazoles with indole derivatives: A new method for synthesis pyranoindoles

A direct and highly stereoselective approach for the synthesis of Z-alkenyl-pyranoindoles had been developed by utilizing Rh(II)-catalyzed intramolecular cyclization of N-sulfonyl-1,2,3-triazoles with indole derivatives. A variety of pyranoindoles were obtained in 44-93% yields. Moreover, a more convenient synthesis of pyranoindoles starting from terminal alkyne was realized via a Cu-Rh sequentially catalyzed one-pot cascade reaction.

A simple and efficient synthesis of ethyl 1-Aryl-4-formyl-1H-pyrazole-3- carboxylates

A new simple and convenient method of synthesis of ethyl 1-aryl-4-formyl-1H-pyrazole-3-carboxylates from aromatic amines via diazonium salts has been developed. Hydrolysis and hydrazinolyization of these compounds has been investigated.