163883-97-4

Basic information

• Product Name: FMOC-DL-(PHENYL)GLY-OH
• Synonyms: FMOC-DL-PHG-OH;FMOC-DL-(PHENYL)GLY-OH;RARECHEM AK ML 0502;N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-DL-PHENYLGLYCINE;FMoc-DL-phenylglycine
• CAS NO: 163883-97-4
• Molecular Formula: C23H19NO4
• Molecular Weight: 373.4
• Mol File: 163883-97-4.mol
• Article Data: 15

Chemical Properties

• Appearance: /
• CAS DataBase Reference: FMOC-DL-(PHENYL)GLY-OH(CAS DataBase Reference)
• NIST Chemistry Reference: FMOC-DL-(PHENYL)GLY-OH(163883-97-4)
• EPA Substance Registry System: FMOC-DL-(PHENYL)GLY-OH(163883-97-4)

Safety Data

• Hazardous Substances Data: 163883-97-4(Hazardous Substances Data)

Upstream product

• 82911-69-1 N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide 
• 2835-06-5 phenylglycin 
• 100-52-7 benzaldehyde 
• 28920-43-6 (fluorenylmethoxy)carbonyl chloride 
• 875-74-1 (R)-phenylglycine 
• 470670-74-7 2,5-dioxo-4-phenyl-oxazolidine-3-carboxylic acid 9H-fluoren-9-ylmethyl ester 
• 2935-35-5 (S)-2-phenylglycine 
• 102410-51-5 H-D-Abu-Pro-OBu^t*TosOH 
• 102419-78-3 Pic(3-OBzl)-Thr(Fmoc-Phg-)-N₂H₃*2*HCl 
• 69-91-0 L-α-phenylglycine 

Downstream Products

• 110116-73-9 H-Tyr-D-Orn<*>-Phg-Asp<*>-NH2 
• 1233241-44-5 Fmoc-L-Phg-Ala-Ψ-[CH2NHCHS] 
• 1233241-45-6 Fmoc-D-Phg-Ala-Ψ-[CH2NHCHS] 
• 1213773-53-5 O-W-F-I-Phg-H(1-Bzl)-NH₂ 
• 1213772-89-4 O-W-Phg-I-F-H(1-Bzl)-NH₂ 

Relevant articles and documents

Development of anti-inflammatory peptidomimetics based on the structure of human alpha1-antitrypsin

Human α1-antitrypsin (hAAT) has two distinguishing functions: anti-protease activity and regulation of the immune system. In the present study we hypothesized that those two protein functions are mediated by different structural domains on the hAAT surface. Indeed, such biologically active immunoregulatory sites (not associated with canonical anti-protease activity) on the surface of hAAT were identified by in silico methods. Several peptides were derived from those immunoregulatory sites. Four peptides exhibited impressive biological effects in pharmacological concentration ranges. Peptidomimetic (14) was developed, based on the structure of the most druggable and active peptide. The compound exhibited a potent anti-inflammatory activity in vitro and in vivo. Such a compound could be used as a basis for developing novel anti-inflammatory drug candidates and as a research tool for better understanding hAAT functions.

IMMUNE CELL MODULATORS

Disclosed are immune cell-selective small molecule compounds that modulate certain immune cell-specific receptors and enzymes, and methods of their synthesis and use to treat proliferative disorders.

Determination of Chemical and Enantiomeric Purity of α-Amino Acids and their Methyl Esters as N-Fluorenylmethoxycarbonyl Derivatives Using Amylose-derived Chiral Stationary Phases

Liquid chromatographic enantiomer separation and simultaneous determination of chemical and enantiomeric purity of α-amino acids and their methyl esters as N-fluorenylmethoxycarbonyl (FMOC) derivatives was performed on three covalently bonded type chiral stationary phases (CSPs) derived from amylose derivatives. The enantiomer separation of α-amino acid esters as N-FMOC derivatives was better than that of the corresponding acids, especially for CSP 1 and 2. Chemical impurities as the corresponding racemic acids present in several commercially available racemic amino acid methyl esters were observed to be 0.49–17.50%. Enantiomeric impurities of several commercially available L-amino acid methyl esters were found to be 0.03–0.58%, whereas chemical impurities as the corresponding racemic acids present in the same analytes were found to be 0.13–13.62%. This developed analytical method will be useful for the determination of chemical and enantiomeric purity of α-amino acids and/or esters as N-FMOC derivatives using amylose-derived CSPs.