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21-Acetoxy-17α-hydroxy-5α-pregnane-3,20-dione is a steroidal compound belonging to the pregnane family, characterized by its unique molecular structure. This chemical features a pregnane core, which is a type of steroid nucleus, with a 3,20-dione group, indicating the presence of two carbonyl groups at the 3 and 20 positions. Additionally, it has a 17α-hydroxy group, which is a hydroxyl group attached to the 17th carbon in the α-configuration, and a 21-acetoxy group, which is an acetyl group attached to the 21st carbon in an ester linkage. 21-acetoxy-17α-hydroxy-5α-pregnane-3,20-dione is known for its potential applications in pharmaceuticals, particularly in the development of drugs targeting hormonal imbalances and other related conditions. Its specific biological activities and therapeutic uses are subject to ongoing research and clinical trials.

1639-45-8

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1639-45-8 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1639-45-8 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,6,3 and 9 respectively; the second part has 2 digits, 4 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 1639-45:
(6*1)+(5*6)+(4*3)+(3*9)+(2*4)+(1*5)=88
88 % 10 = 8
So 1639-45-8 is a valid CAS Registry Number.

1639-45-8Upstream product

1639-45-8Relevant academic research and scientific papers

The scarlet letter: Reichstein's substance S. A comparison of the angiostatic properties of 5α-tetrahydro S and 5β-tetrahydro S

Hadd, Harry E.

, p. 650 - 655 (1995)

5β-Tetrahydro-Reichtein's Substance S (3α, 5β-THS) from different sources yielded variable bioassays activity in the chick chorio-allantoic membrane assay system. Physical characterization showed impure products. Synthesis of this compound by two different routes yielded active and inactive 3α,5β-THS. Of the other two epimers, 3β,5β-THS (epi-THS) and 3α,5α-THS (allo-THS), only the latter was active. These results suggest that the impurities present in 3α,5β-THS synthesized by reduction of the α,β-unsaturated ketone of Substance S might be either or both the epi- lallo-epimers (3β,5β-THS and 3α,5α-THS, respectively), with only the latter contributing the positive angiostatic activity to the mixture. Of the two synthetically derived compounds, only the latter was shown to maintain the activity, whereas 3α,5β-THS was not antiangiogenic.

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