163923-18-0Relevant articles and documents
PROCESS FOR THE PREPARATION OF SALMETEROL AND ITS INTERMEDIATES
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Page/Page column 27, (2012/03/27)
The present invention discloses a process for the preparation of methyl 2-(benzyloxy)- 5-(2-bromoacetyl)benzoate (V), comprising: (d) benzylating methyl-5-acetyl-2-hydroxybenzoate (VIII) with benzyl chloride in the presence of a base and a catalyst in a suitable polar solvent to obtain 5-acetyl-2- benzyloxy benzoate (VII); (e) brominating methyl 5-acetyl-2-(benzyloxy)benzoate (VII) with a suitable brominating agent in one or more suitable' solvents in the presence of an acid catalyst to obtain methyl 2-(benzyloxy)-5-(2-bromoacetyl)benzoate V; (c) optionally, purifying the methyl 2-(benzyloxy)-5-(2-bromoacetyl)benzoate (V) in a suitable solvent; and (f) isolating the methyl 2-(benzyloxy)-5-(2-bromoacetyl)benzoate (V).
NOVEL PROCESS
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Page/Page column 24, (2010/11/27)
The present invention relates to processes for the preparation of 4- hydroxy-α'' -[[[6-(4-phenylbutoxy)hexyl]amino]methyl]- 1,3-benzenedimethanol 1-hydroxy-2-naphthoate (salmeterol xinafoate) (Formula (12a)), the preparation of 4-hydroxy-α''-[[[6-(4-phenylbutoxy)hexyl]amino]methyl]-1,3-benzenedimethanol (salmeterol) (Formula (11)), the preparation of protected N-[6-(4-phenylbutoxy)hexyl]amine intermediates (Formula (7)), and the preparation of 6-substituted (4-phenylbutoxy)hexane intermediates (Formula (5)), shown below, wherein X is a leaving group and Pg is a protecting group.