163981-89-3

Upstream product

• 3490-06-0 N-methylhomoveratrylamine 
• 36770-74-8 N-(3-chloropropyl)-3,4-dimethoxy-N-methylphenethylamine 
• 1026432-88-1 1-(3-{[2-(3,4-Dimethoxy-phenyl)-ethyl]-methyl-amino}-propyl)-piperidin-4-one 
• 120-20-7 2-(3,4-dimethoxyphenyl)-ethylamine 
• 1027036-42-5 1-(3-{[2-(3,4-Dimethoxy-phenyl)-ethyl]-methyl-amino}-propyl)-piperidin-4-one oxime 

Relevant academic research and scientific papers

Synthesis and Activity against Multidrug Resistance in Chinese Hamster Ovary Cells of New Acridone-4-carboxamides

A number of tricyclic carboxamides have been synthesized and tested to evaluate their ability to reverse multidrug resistance in the CHRC/5 cell line.Among them the acridone derivatives were the most potent.A key feature is the presence of a dimethoxybenzyl or phenethylamine cationic site, separated from the tricyclic lipophilic part by a carbamoylphenyl chain.Optimization led to compounds 2 orders of magnitude more active than the prototype inhibitors verapamil and amiodarone.On the basis of in vitro and in vivo activities, 9,10-dihydro-5-methoxy-9-oxo-N-phenyl>-4-acridinecarboxamide (84) has been selected for further development.