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16401-66-4

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16401-66-4 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 16401-66-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,6,4,0 and 1 respectively; the second part has 2 digits, 6 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 16401-66:
(7*1)+(6*6)+(5*4)+(4*0)+(3*1)+(2*6)+(1*6)=84
84 % 10 = 4
So 16401-66-4 is a valid CAS Registry Number.

16401-66-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name N-methylquinolin-4-amine

1.2 Other means of identification

Product number -
Other names [4]quinolyl-methyl-amine

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:16401-66-4 SDS

16401-66-4Downstream Products

16401-66-4Relevant articles and documents

Hydrolysis of 4-amino-3-quinolinesulfonamides

Skrzypek, Leszek

, p. 1249 - 1254 (1998)

Acid hydrolysis of 4-amino-3-quinolinesulfonamides (3) gives 1,4-dihydro-4-oxo-3-quinolinesulfonamides (4), 4-aminoquinolines (5) or a mixture of these compounds. Part LIII in the series of Azinyl Sulfides.

Introduction of alkylamino and dialkylamino groups into the quinoline

LUTHY,BERGSTROM,MOSHER

, p. 1109 - 1109 (1949)

-

Structure-activity relationships for ferriprotoporphyrin IX association and β-hematin inhibition by 4-aminoquinolines using experimental and ab initio methods

Nsumiwa, Samkele,Kuter, David,Wittlin, Sergio,Chibale, Kelly,Egan, Timothy J.

supporting information, p. 3738 - 3748 (2013/07/19)

In order to probe structure-activity relationships of association with ferriprotoporphyrin IX (log K) and inhibition of β-hematin formation, a series of 4-aminoquinolines with varying substituents at the 7-position (X) have been synthesized. These have been further elaborated by introduction of two different R groups on the 4-amino nitrogen atom in the form of methyl (R = Me) and ethylamine (R = EtNH2) side chains. Data for a previously investigated series containing an N,N-diethyl-ethylamine side chain were also compared with the findings of this study. Experimentally, log K values for the simple 4-aminoquinoline series (R = H) were found to correlate with the hydrophobicity constant (π) of the group X. The log K values for the series with R = Me and EtNH2 were found to correlate with those of the series with R = H. The log of the 50% β-hematin inhibitory activity (log BHIA50) was found to correlate with log K and either meta (σm) or para (σp) Hammett constants for the series with R = Me and EtNH2, but not the simple series with R = H. To further improve predictability, correlations with ab initio electrostatic parameters, namely Mulliken and CHelpG charges were investigated. The best correlations were found with CHelpG charges which indicated that log K values can be predicted from the charges on atom H-8 and the group X in the quinolinium species computed in vacuum, while log BHIA50 values can be predicted from the CHelpG charges on C-7, C-8 and N-1 for the neutral species in vacuum. These correlations indicate that association and inhibition of β-hematin formation are separately determined. They also suggest that electron withdrawing groups at the 7-position, but not necessarily hydrophobic groups are required for hemozoin inhibition. The upshot is that the correlations imply that considerably more hydrophilic hemozoin inhibitors are feasible.

PERACID OXIDATION OF (METHYLAMINO)QUINOLINES

Pentimalli, Luciano,Milani, Giovanni

, p. 803 - 806 (2007/10/02)

The peracid oxidation of 2-(dimethylamino)quinoline yields the amino oxide; from 2-methylamino- and 4-dimethylamino-quinoline the corresponding 1-oxides are obtained. 2-Dimetylamino- and 4-dimethylamino-quinoline 1-oxide can only be obtained via chloroquinoline 1-oxide.

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