164071-20-9Relevant academic research and scientific papers
Unprecedented iron-catalyzed ester hydrogenation. Mild, selective, and efficient hydrogenation of trifluoroacetic esters to alcohols catalyzed by an iron pincer complex
Zell, Thomas,Ben-David, Yehoshoa,Milstein, David
supporting information, p. 4685 - 4689 (2014/05/20)
The synthetically important, environmentally benign hydrogenation of esters to alcohols has been accomplished in recent years only with precious-metal-based catalysts. Here we present the first iron-catalyzed hydrogenation of esters to the corresponding alcohols, proceeding selectively and efficiently in the presence of an iron pincer catalyst under remarkably mild conditions. The replacement of precious-metal catalysts by an iron complex was accomplished for the synthetically important, environmentally benign hydrogenation of esters to alcohols under mild conditions. The iron pincer complex (see scheme) selectively and efficiently catalyzes the hydrogenation of trifluoroacetates under remarkably mild conditions (5-25 bar and 40 °C).
Heterolytic decarboxylation involving acyltrifluoroacetyl peroxide intermediates
Krasutsky, Pavel A.,Kolomitsyn, Igor V.,Botov, Evgenij M.,Carlson, Robert M.,Semenova, Irina G.,Fokin, Andrey A.
, p. 8687 - 8691 (2007/10/03)
Selective carboxylic acid decarboxylation was elaborated. Generation of acyltrifluoroacetyl peroxides from carboxylic peracids and trifluoroacetyl anhydride (Method A), as well as from trifluoroperacetic acid and acyltrifluoroacetyl anhydride (Method B), leads to simultaneous peroxide decomposition into the corresponding alkyltrifluoroacetates. DFT computations, as well as experimental data, support an acid-catalyzed heterolytic mechanism for acyltrifluoroacetyl peroxide decomposition.
