164084-29-1

Usage

Chemical Family

1H-Indole-3-acetamide

Derivative

Indole with a phenylmethyl group, ethyl and methoxy substituents

Biological Activities

Known for its biological activities

Potential Uses

Anti-inflammatory and analgesic agent, synthesis of pharmaceuticals, treatment of neurological disorders and cancer

Chemical Structure

Makes it a subject of interest in the development of new therapeutic agents and pharmaceuticals

Upstream product

• 30414-53-0 methyl propanoyl acetate 
• 184705-06-4 methyl 3-(benzylamino)pent-2-enoate 
• 100-46-9 benzylamine 
• 102-50-1 2-methyl-4-methoxyaniline 
• 163688-10-6 2-ethyl-5-methoxy-1H-indole 
• 163688-11-7 2-ethyl-5-methoxy-1-(phenylmethyl)-1H-indole-3-acetic acid methyl ester 
• 163688-09-3 1-[2-(tert-butoxycarbonylamino)-5-methoxyphenyl]-2-butanone 
• 41800-12-8 2-ethyl-5-methoxyindole-3-acetic acid methyl ester 
• 129822-42-0 N-(tert-butoxycarbonyl)-4-methoxy-2-methylaniline 
• 184705-08-6 3-(carbomethoxy)-2-ethyl-1-(phenylmethyl)-5-methoxyindole 
• 184705-11-1 3-(hydroxymethyl)-2-ethyl-1-(phenylmethyl)-5-methoxyindole 
• 184705-03-1 1-benzyl-2-ethyl-5-hydroxy-1H-indole-3-carboxylic acid methyl ester 
• 163734-44-9 2-ethyl-5-methoxy-1-(phenylmethyl)-1H-indole-3-acetic acid hydrazide 
• 184705-14-4 3-(cyanomethyl)-2-ethyl-1-(phenylmethyl)-5-methoxyindole 

Downstream Products

• 164083-83-4 dimethyl [3-[[3-(amidomethyl)-2-ethyl-1-(phenylmethyl)-indol-5-yl]oxy]propyl]phosphonate 
• 164083-79-8 ethyl [4-[3-(amidomethyl)-2-ethyl-1-(phenylmethyl)-indol-5-yl]oxy]butanoate 
• 164083-16-3 [3-[[4-allyl-3-(2-amino-2-oxoethyl)-2-ethyl-1-(phenylmethyl)-1H-indol-5-yl]oxy]propyl]phosphonic acid dimethyl ester 
• 164084-20-2 2-[[[3-(2-amino-2-oxoethyl)-2-ethyl-1-(phenylmethyl)-1H-indol-5-yl]oxy]methyl]benzoic acid methyl ester 
• 164083-81-2 2-ethyl-5-(4-hydrazino-4-oxobutoxy)-1-(phenylmethyl)-1H-indole-3-acetamide 
• 164084-15-5 2-(4-Allyl-1-benzyl-2-ethyl-5-hydroxy-1H-indol-3-yl)-acetamide 
• 164083-15-2 2-(5-Allyloxy-1-benzyl-2-ethyl-1H-indol-3-yl)-acetamide 
• 164123-34-6 3-(amidomethyl)-2-ethyl-1-(phenylmethyl)-5-hydroxyindole 

Relevant academic research and scientific papers

Synthesis of indomethacin analogues for evaluation as modulators of MRP activity

Synthesis of a range of indomethacin analogues, required for investigation in combination toxicity assays, bearing both N-benzyl and N-benzoyl groups, is described. Copyright

Indole inhibitors of human nonpancreatic secretory phospholipase A2. 1. Indole-3-acetamides

Phospholipases (PLAs) produce rate-limiting precursors in the biosynthesis of various types of biologically active lipids involved in inflammatory processes. Increased levels of human nonpancreatic secretory phospholipase A2 (hnps-PLA2) have been detected in several pathological conditions. An inhibitor of this enzyme could have therapeutic utility. A broad screening program was carried out to identify chemical structures which could inhibit hnps-PLA2. One of the lead compounds generated by the screening program was 5-methoxy-2-methyl-1-(phenylmethyl)-1H-indole-3-acetic acid (13a). We describe the syntheses, structure-activity relationships, and pharmacological activities of a series of indole-3-acetamides and related compounds derived from this lead. This SAR was undertaken with the aid of X- ray crystal structures of complexes between the inhibitors and hnps-PLA2 which were of great value in directing the SAR.