164120-30-3Relevant academic research and scientific papers
Synthesis and preliminary in vitro evaluation of antitumor nitrosoureido cholesterol derivatives
Elkihel,Gelin,Letourneux
, p. 190 - 194 (2007/10/02)
A new class of chloroethyl nitrosourea analogues of cholesterol has been synthetized from the corresponding 7-amino and 7-aminoalkylcholesterol derivatives. Compounds III-V inhibited L1210 cell growth in culture much more effectively than N,N'-bis(2-cgloroethyl)-N'-nitrosourea (BCNU) after 48 h incubation. Stability and cytotoxic activity of these prodrugs are promising for brain tumor treatments and as lymphotropic vectors for tumor cells spreading along the lymphatic pathways.
