164159-99-3Relevant academic research and scientific papers
A practical regiospecific synthesis of 9-nitrocamptothecin
Fu, Qingquan,Chen, Zhiyong
, p. 1940 - 1942 (2007/10/03)
9-Nitrocamptothecin has shown potent antitumor activity against many types of human cancers. A practical scale-up procedure for this compound is reported by selective reduction of corresponding sulfonate. Georg Thieme Verlag Stuttgart.
Synthesis and antitumor activity of a new class of water soluble camptothecin derivatives
Bedeschi, Angelo,Zarini, Franco,Cabri, Walter,Candiani, Ilaria,Penco, Sergio,Capolongo, Laura,Ciomei, Marina,Farao, Mariella,Grandi, Maria
, p. 671 - 674 (2007/10/03)
A new family of water soluble camptothecin derivatives is described. Their synthesis, in vitro cytotoxicity, and in vivo antitumor activity is reported. Compounds 5a and 5c displayed excellent in vivo antitumor activity both ip and iv.
A new high yield semisynthetic approach to (20S)-9-NH2-Camptothecin based on a sequence of palladium-catalysed reductions
Cabri, Walter,Candiani, Ilaria,Zarini, Franco,Penco, Sergio,Bedeschi, Angelo
, p. 9197 - 9200 (2007/10/02)
A new 5-step synthesis of 9-NH2-Camptothecin starting from natural Camptothecin is described. The approach, centred on a double palladium catalysed reduction of an arylsulfonate and a nitro group, has an overall yield consistently higher than the previously reported ones.
