164159-99-3Relevant articles and documents
A practical regiospecific synthesis of 9-nitrocamptothecin
Fu, Qingquan,Chen, Zhiyong
, p. 1940 - 1942 (2007/10/03)
9-Nitrocamptothecin has shown potent antitumor activity against many types of human cancers. A practical scale-up procedure for this compound is reported by selective reduction of corresponding sulfonate. Georg Thieme Verlag Stuttgart.
A new high yield semisynthetic approach to (20S)-9-NH2-Camptothecin based on a sequence of palladium-catalysed reductions
Cabri, Walter,Candiani, Ilaria,Zarini, Franco,Penco, Sergio,Bedeschi, Angelo
, p. 9197 - 9200 (2007/10/02)
A new 5-step synthesis of 9-NH2-Camptothecin starting from natural Camptothecin is described. The approach, centred on a double palladium catalysed reduction of an arylsulfonate and a nitro group, has an overall yield consistently higher than the previously reported ones.