104267-73-4Relevant articles and documents
A new high yield semisynthetic approach to (20S)-9-NH2-Camptothecin based on a sequence of palladium-catalysed reductions
Cabri, Walter,Candiani, Ilaria,Zarini, Franco,Penco, Sergio,Bedeschi, Angelo
, p. 9197 - 9200 (1995)
A new 5-step synthesis of 9-NH2-Camptothecin starting from natural Camptothecin is described. The approach, centred on a double palladium catalysed reduction of an arylsulfonate and a nitro group, has an overall yield consistently higher than the previously reported ones.
Radiosynthesis of carbon-11-labeled camptothecin derivatives as potential positron emission tomography tracers for imaging of topoisomerase I in cancers
Gao, Mingzhang,Miller, Kathy D.,Sledge, George W.,Zheng, Qi-Huang
, p. 3865 - 3869 (2005)
Four carbon-11-labeled camptothecin derivatives, 9-[11C]methoxy- 20(S)-camptothecin ([11C]5), 10-[11C]methoxy-20(S)- camptothecin ([11C]7), 9-nitro-10-[11C]methoxy-20(S)- camptothecin ([11C]9), and 9-[([11C]trimethylamino)methyl] -10-hydroxy-20(S)-camptothecin ([11C]11), have been synthesized as potential positron emission tomography tracers for imaging of topoisomerase I in cancers.
Synthesis and antitumor activity of a new class of water soluble camptothecin derivatives
Bedeschi, Angelo,Zarini, Franco,Cabri, Walter,Candiani, Ilaria,Penco, Sergio,Capolongo, Laura,Ciomei, Marina,Farao, Mariella,Grandi, Maria
, p. 671 - 674 (2007/10/03)
A new family of water soluble camptothecin derivatives is described. Their synthesis, in vitro cytotoxicity, and in vivo antitumor activity is reported. Compounds 5a and 5c displayed excellent in vivo antitumor activity both ip and iv.