164172-51-4Relevant academic research and scientific papers
Utilization of Solid Acid SO42?/TiO2 as Catalyst to the Three-Component Mannich Reaction at Ambient Temperature
Yao, Yuanyong,Zhang, Meng,Chen, Shixue,Xing, Mingming,Shu, Hua
, p. 2520 - 2528 (2017)
The three-component Mannich reaction of among dimethyl malonate, aromatic primary amine, and aromatic aldehyde was made successfully in the presence of solid acidic catalyst SO42?/TiO2, with excellent catalytic
Mechanistic details of amino acid catalyzed two-component Mannich reaction: experimental study backed by density functional calculations
Rani, Dixita,Thakur, Lalita,Khera, Mayank,Goel, Neetu,Agarwal, Jyoti
, p. 1609 - 1621 (2019/11/20)
The role of pH-dependent ionic structures of l-amino acids in catalysis has been investigated for the two-component Mannich reactions between dimethyl malonate (DMM)/ethyl acetoacetate (EAA) and imines. As catalysts, l-amino acids performed well, even bet
One-pot synthesis of mannich bases under solvent-free conditions
Demirkol, Onur,Akbaslar, Dilek,Giray, Sultan,Anil, B. Baris
supporting information, p. 1279 - 1285 (2014/04/17)
A mild and practically convenient one-pot procedure for the Mannich reaction via condensation of amines, aldehydes and malonates, β-ketoesters, or β-dicarbonyl compounds has been carried out without using any organic solvent, metallic catalyst, or Lewis acids or bases at room temperature. The present protocol offers several advantages, such as goods yields, simple procedure with easy workup, and the absence of any volatile, hazardous organic solvents and metallic catalyst.
