164263-06-3Relevant academic research and scientific papers
Determination of the absolute configuration of biologically active (S)-(-)-NB 818 and its structural correlation with the stereoselectivity of the channel blocking action
Yamazaki,Ebiike,Achiwa
, p. 1968 - 1970 (1994)
The absolute configuration of 4-(2,3-dichlorophenyl)-1,4-dihydropyridines was established by chemical correlation with (S)-(-)-felodipine, the absolute configuration of which had been determined by X-ray analysis.
Asymmetric synthesis of (R)-nilvadipine and (S)-NB 818 via regioselective bromination of chiral 1,4-dihydropyridines as a key step and enzymatic resolution of racemic 2-hydroxymethyl-1,4-dihydropyridine derivatives
Ebiike, Hirosato,Maruyama, Kaori,Ozawa, Yumi,Yamazaki, Yukiyoshi,Achiwa, Kazuo
, p. 869 - 876 (2007/10/03)
Optically active 2-hydroxymethyl-1,4,dihydropyridines were obtained by lipase-catalyzed hydrolysis or transesterification of racemic materials. Chiral NB 818 and nilvadipine have been synthesized from chiral 2- hydroxymethyl-1,4-dihydropyridine. On the ot
