Determination of the absolute configuration of biologically active (S)-(-)-NB 818 and its structural correlation with the stereoselectivity of the channel blocking action

DOI: 10.1248/cpb.42.1968

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 1968 - 1970 (1994)

Update date:2022-07-30

Topics: Enantioselective synthesis X-ray crystallography Stereoselectivity Chirality Structural Correlation Absolute Configuration Patch-clamp electrophysiology

Authors:

Yamazaki

Ebiike Ebiike

Achiwa Achiwa

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Article abstract of DOI:10.1248/cpb.42.1968

The absolute configuration of 4-(2,3-dichlorophenyl)-1,4-dihydropyridines was established by chemical correlation with (S)-(-)-felodipine, the absolute configuration of which had been determined by X-ray analysis.

Full text of DOI:10.1248/cpb.42.1968

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