1642790-75-7Relevant academic research and scientific papers
Fosmidomycin analogues with N-hydroxyimidazole and N-hydroxyimidazolone as a chelating unit
Midrier, Camille,Montel, Sonia,Braun, Ralf,Haaf, Klaus,Willms, Lothar,Van Der Lee, Arie,Volle, Jean-Noel,Pirat, Jean-Luc,Virieux, David
, p. 23770 - 23778 (2014/07/07)
Fosmidomycin has been reported to have many biological activities as an antibacterial and antimalarial, along with being a herbicidal agent. Its unique mode of action involves the inhibition of a key step of the non mevalonate pathway by blockade of a crucial enzyme, the 1-deoxy-d-xylulose 5-phosphate reductoisomerase (DXR), whose expression is present in bacteria, plasmodium parasites and higher plants, but not in mammals. Herein we report the development of fosmidomycin and of FR-900098 constrained analogues belonging to an unusual heterocyclic based complexing subunit involving N-hydroxyimidazoles and cyclic N-hydroxyureas.
