1643-71-6

Upstream product

• 4126-86-7 1,2,4,5-Tetrafluor-3-methoxy-6-nitroso-benzol 
• 1887-73-6 4-methoxy-2,3,5,6-tetrafluoronitrobenzene 
• 100758-22-3 benzylidene 4-methoxy-2,3,5,6-tetrafluoroaniline 
• 186581-53-3 diazomethane 
• 938-63-6 4-amino-2,3,5,6-tetraflourophenol 
• 880-78-4 pentafluoronitrobenzen 
• 1423-13-8 pentafluoronitrosobenzene 
• 2324-98-3 2,3,5,6-tetrafluoroanisole 
• 1801-15-6 2-(2,3,4,5,6-pentafluoro-anilino)-ethanol 
• 30807-79-5 C₆HBCl₂F₅N 
• 771-60-8 2,3,4,5,6-pentafluoroaniline 
• 124-41-4 sodium methylate 

Downstream Products

• 2787-85-1 4,4'-CH₃O-C₆F₄N(O)NC₆F₄OCH₃ 
• 63995-39-1 C₇H₃Cl₂F₄NO 
• 88785-40-4 C₇H₃F₄NO₂S 
• 2010-70-0 2,3,5,6-tetrafluoro-4-methoxyacetanilide 
• 124700-60-3 4-Methoxy-2,3,5,6-tetrafluoro-N-(2'-hydroxybenzylidene)aniline 
• 488728-67-2 2,3,5,6-tetrafluoro-4-methoxyphenylmaleimide 
• 80588-61-0 N-(2,3,5,6-Tetrafluoro-4-methoxy-phenyl)-benzamide 

Relevant academic research and scientific papers

(NHC)Cu-Catalyzed Mild C-H Amidation of (Hetero)arenes with Deprotectable Carbamates: Scope and Mechanistic Studies

Primary arylamines are an important unit broadly found in synthetic, biological, and materials science. Herein we describe the development of a (NHC)Cu system that mediates a direct C-H amidation of (hetero)arenes by using N-chlorocarbamates or their sodio derivatives as the practical amino sources. A facile stoichiometric reaction of reactive copper-aryl intermediates with the amidating reagent led us to isolate key copper arylcarbamate species with the formation of a C-N bond. The use of tBuONa base made this transformation catalytic under mild conditions. The present (NHC)Cu-catalyzed C-H amidation works efficiently and selectively on a large scale over a range of arenes including polyfluorobenzenes, azoles, and quinoline N-oxides. Deprotection of the newly installed carbamate groups such as Boc and Cbz was readily performed to afford the corresponding primary arylamines.

Fluorine-containing phenylmaleimide derivative, polymer, chemically amplified resist composition, and method for pattern formation using the composition

A fluorine-containing phenylmaleimide derivative having a specific structure. A polymer obtained by polymerizing monomers containing the derivative. A polymer containing a specific structural unit and having a weight-average molecular weight of 2,000 to 2

The effect of fluorine substitution on the physicochemical properties and the analgesic activity of paracetamol

The physicochemical properties and analgesic action of six fluorinated analogues of 4-hydroxyacetanilide (paracetamol) have been investigated. Fluorine substitution adjacent to the hydroxyl group increased lipophilicity and oxidation potential whilst substitution adjacent to the amide had little effect on lipophilicity but led to a greater increase in oxidation potential. Lack of coplanarity and conjugation of the amide group and aromatic ring was also apparent with the analogues that had fluorine in the 2 and 6 positions. Introduction of fluorine into the amide group of paracetamol increased the lipophilicity 4-fold and also increased the oxidation potential of paracetamol. ED50 values for analgesic activity in the phenylquinone-induced abdominal constriction test on male Swiss White mice showed that ring substitution by fluorine reduced activity, especially at the 2,6-positions. Introduction of fluorine into the amide group enhanced activity significantly. Correlation of the analgesic activity with the physicochemical properties indicated that conjugation (and planarity) of the amide group with the aromatic ring is essential for activity and that ease of oxidation may also be an important factor.