1643565-07-4

Upstream product

• 4070-48-8 L-Valine methyl ester 
• 696-62-8 para-iodoanisole 
• 211568-63-7 (S)-tert-butyl 1-azido-3-methylbutan-2-ylcarbamate 
• 122818-28-4 (S)-2-(N-tert-butoxycarbonylamino)-3-methylbutyl tosylate 
• 72-18-4 L-valine 
• 79069-14-0 (S)-2-<(tert-butoxycarbonyl)amino>-3-methylbutan-1-ol 
• 58561-04-9 N-tert-butoxycarbonyl-L-valine methyl ester 

Relevant academic research and scientific papers

A rapid entry to amino acid derived diverse 3,4-dihydropyrazines and dihydro[1,2,3]triazolo[1,5-a]pyrazines through 1,3-dipolar cycloaddition

An efficient, general and practical synthesis of diverse 3,4-dihydropyrazines, 6,7-dihydro-[1,2,3]triazolopyrazines and 7,8-dihydro-[1,2,3]triazolodiazepines through intramolecular 1,3-dipolar cycloaddition from amino acid derived common intermediates with high yields is described. Moreover, one-pot access to optically active 3-aryl substituted 6,7-dihydro-[1,2,3]triazolo[1,5-a]pyrazines in the palladium-copper co-catalytic system has also been achieved in this work. The easy substrate availability and operational simplicity make the process suitable for further exploration. This journal is the Partner Organisations 2014.