164363-75-1

Upstream product

• 90841-43-3 (E)-4-methoxycinnamyl bromide 
• 53484-50-7 (E)-p-methoxy-cinnamyl alcohol 
• 81701-30-6 (E)-4-methoxycinnamyl acetate 
• 24680-50-0 4-methoxy-trans-cinnamaldehyde 
• 140-67-0 Estragole 
• 3536-96-7 vinylmagnesium chloride 
• 123-11-5 4-methoxy-benzaldehyde 
• 943-89-5 (E)-3-(4-methoxyphenyl)acrylic acid 

Downstream Products

• 20850-13-9 (E)-3-(4-methoxyphenyl)prop-2-en-1-amine 
• 1286255-93-3 (5S,6R)-2-(4-bromophenyl)-5-chloro-6-(4-methoxyphenyl)-5,6-dihydro-4H-1,3-oxazine 
• 1286255-78-4 (E)-4-bromo-N-[3-(4-methoxyphenyl)allyl]benzamide 
• 14482-11-2 (E)-p-methoxycinnamonitrile 
• 1225705-84-9 (2-(4-methoxyphenyl)cyclopropyl)methanamine 
• 1266871-30-0 (2-(4-methoxyphenyl)cyclopropyl)-N-methylmethanamine 
• 1610026-25-9 (E)-1-(3-(4-methoxyphenyl)allyl)-4-phenyl-1H-1,2,3-triazole 

Relevant academic research and scientific papers

Further investigation of harmicines as novel antiplasmodial agents: Synthesis, structure-activity relationship and insight into the mechanism of action

The rise of the resistance of the malaria parasite to the currently approved therapy urges the discovery and development of new efficient agents. Previously we have demonstrated that harmicines, hybrid compounds composed from β-carboline alkaloid harmine

Direct Conversion of Aldehydes and Ketones into Azides by Sequential Nucleophilic Addition and Substitution

This report describes the direct conversion of aldehydes and ketones into alkyl azides by the addition of common organometallic reagents and tandem conversion of the resulting alkoxides without isolation of the intermediate alcohols. A wide range of aldehydes and organometallic reagents (R–Li or R–MgX) are suitable participants in this process. Additional reaction telescoping beyond azide formation is demonstrated.

Palladium-catalyzed regioselective azidation of allylic C-H bonds under atmospheric pressure of dioxygen

A palladium-catalyzed allylic azidation of alkenes with sodium azide under atmospheric pressure of dioxygen was developed. This methodology provides a new efficient and simple route for accessing allylic azides. Furthermore, the one-pot process consisting of Pd-catalyzed allylic azidation of alkenes and Cu-catalyzed 1,3-dipolar cycloaddition led directly to the 1,2,3-triazole from the alkene. The formed allylic azide can be also in situ reduced to the allylic amine or oxidized to the alkenyl nitrile. the Partner Organisations 2014.

A domino microwave-assisted protocol for the synthesis of 2,6-disubstituted pyrimidinones

A practical microwave-assisted protocol for the synthesis of 2,6-disubstituted pyrimidinones has been developed. This approach is based on a domino Michael addition-cyclocondensation reaction between substituted thioureas/guanidines and acetylenecarboxyla

An efficient approach to alkenyl nitriles from allyl esters

A novel and efficient approach to alkenyl nitriles from allyl esters has been developed. A tandem Pd-catalyzed substitution and the subsequent oxidative rearrangement are involved in this transformation. The method provides an important supplement for the synthesis of alkenyl nitriles from allyl esters. Georg Thieme Verlag Stuttgart · New York.

A catalytic asymmetric chlorocyclization of unsaturated amides

The asymmetric chlorocyclization of unsaturated amides catalyzed by (DHQD)2PHAL yields oxazoline and dihydrooxazine derivatives (see scheme). The reaction is operationally simple and employs 1-2 mol % of the commercially available (DHQD)2PHAL (hydroquinidine 1,4-phthalazinediyl diether) catalyst. Different substitution patterns of the olefin as well as aromatic and aliphatic olefin substituents are well tolerated. DCDPH=N,N-dichloro-5,5-diphenylhydantoin. Copyright

Cycloadditions by oxidative visible light photocatalysis

Photochemical reactions are remarkable for their ability to easily assemble cyclobutanes and other strained ring systems that are difficult to construct using other conventional synthetic methods. We have previously shown that Ru(bpy)32+ is an efficient photocatalyst that promotes the [2+2] cycloadditions of electron-deficient olefins with visible light. Here, we show that Ru(bpy)32+ is also an effective photocatalyst for the [2+2] cycloaddition of electron-rich olefins. This transformation is enabled by the versatile photoelectrochemical properties of Ru(bpy) 32+, which enables either one-electron reduction or one-electron oxidation of interesting organic substrates under appropriate conditions.

π-allylic azidation in water with an amphiphilic resin-supported palladium-phosphine complex

π-Allylic azidation of allyl esters was performed with an amphiphilic polystyrene-poly(ethylene glycol) (PS-PEG) resin-supported phosphine-palladium complex in water under hetero-geneous conditions to give allyl azides in good to high yields. The polymeric palladium catalyst can be readily recovered and recycled. Georg Thieme Verlag Stuttgart.