164391-52-0

Usage

Uses

Used in Perfumery and Personal Care Industry:
2(3H)-Benzofuranone, 5,7-bis(1,1-dimethylethyl)-3-(3,4-dimethylphenyl)is used as a fragrance ingredient for its unique and appealing scent. It adds depth and complexity to perfumes and personal care products, enhancing the overall sensory experience for consumers.
Used in Food Industry:
In the food industry, 2(3H)-Benzofuranone, 5,7-bis(1,1-dimethylethyl)-3-(3,4-dimethylphenyl)serves as a flavoring agent. Its distinct aroma and taste profile contribute to the development of innovative and appealing flavors in food products, providing a pleasant sensory experience for consumers.
Used in Pharmaceutical Applications:
Due to its anti-inflammatory and antioxidant properties, 2(3H)-Benzofuranone, 5,7-bis(1,1-dimethylethyl)-3-(3,4-dimethylphenyl)has potential applications in the pharmaceutical industry. It may be used in the development of medications targeting inflammation and oxidative stress-related conditions, offering therapeutic benefits to patients.
Used in Cosmetic Applications:
In the cosmetic industry, 2(3H)-Benzofuranone, 5,7-bis(1,1-dimethylethyl)-3-(3,4-dimethylphenyl)can be utilized for its antioxidant properties. It may be incorporated into skincare and beauty products to protect the skin from oxidative damage, promoting a healthier and more youthful appearance.
However, it is crucial to handle this chemical with care, as it may cause skin and eye irritation if not properly managed. Proper safety measures should be taken during its use in various applications to ensure the well-being of consumers and workers in the industry.

Upstream product

• 95-47-6 o-xylene 
• 96-76-4 2,4-di-tert-Butylphenol 
• 298-12-4 Glyoxilic acid 
• 163489-63-2 5,7-di-tert-butyl-3-hydroxy-3H-benzofuran-2-one 
• 252961-08-3 2,4-di-tert-butyl-6-[dimethylamino-(3,4-dimethyl-phenyl)-methyl]-phenol 
• 5973-71-7 3,4-dimethylbenzaldehyde 
• 387365-66-4 5,7-di-tert-butyl-3-(3,4-dimethylphenyl)benzofuran-2-ylamine 

Downstream Products

• 252961-15-2 3,5-di-tert-butyl-2-hydroxy-phenyl-(3,4-dimethyl-phenyl)-methanone 
• 264285-78-1 HP-136 radical 

Relevant academic research and scientific papers

Sequential Continuous-Flow Synthesis of 3-Aryl Benzofuranones

A sequential continuous-flow system to produce 3-aryl benzofuranones was developed. Starting from 2,4-di-tert-butylphenol and glyoxylic acid monohydrate, both the initial cyclocondensation and the subsequent Friedel?Crafts alkylation were catalyzed by the same heterogeneous catalyst, Amberlyst-15H. The catalyst has a promising life-time for these two steps, and it was able to be recovered and reused for several runs without deactivation. By using the established flow system, 5,7-di-tert-butyl-3-(3,4-dimethylphenyl)-3H-benzofuran-2-one (Irganox HP-136), which is a commercial antioxidant, was prepared in 88% two-step yield. Reactions with various aromatic compounds proceeded well under flow conditions to afford 3-aryl benzo-furanone derivatives in high yields with good functional group compatibility.

Efficient catalytic synthesis method of antioxidant HP-136

The invention discloses an efficient catalytic synthesis method of adopting 2,4-di-tert-butyl phenol, a glyoxylic acid solution and o-xylene as raw materials for synthesizing an antioxidant HP-136. According to the method, the raw materials are easily obtained, the operation is simple, the reaction conditions are mild, the yield of products is high, and the purity is high. The provided efficient catalytic synthesis method of the antioxidant HP-136 opens up a new low-cost environment-friendly path for the novel antioxidant and has the advantages that the sources of the raw materials are wider,the selectivity and yield of the target products are high, the reaction conditions are mild, the reaction operation is simple, and meanwhile, no harmful by-products are generated, so that the method is environmentally friendly.

A Concise Route to 2-Amino-3-aryl-3H-benzofurans and their Use as Precursors to 3-Aryl-3H-benzofuran-2-one and 1H-Benzofuro[2,3-￡]pyridin-2- one Derivatives

A concise approach to 2-amino-3-aryl-3H-benzofurans based on the Michael addition of NaCN onto in situ generated substituted o-quinone methides has been developed. Straightforward access to 3-aryl-3H-benzofuran-2-ones was achieved upon acidic hydrolysis whereas JV-Boc-protected 2-amino-3-aryl-3H-benzofurans underwent smooth intramolecular cyclisation to give 1H-benzofuro[2,3-b]pyridin- 2-one derivatives.

Process for the preparation of 3-aryl-benzofuranones

Process for the preparation of compounds of formula (I), wherein the general symbols are as defined in claim1, which process comprises reacting a compound of formula (V), wherein the general symbols are as defined in claim1, with carbon monoxide in the presence of a catalyst.

3-arylbenzofuranones as stabilizers

The invention described novel compounds of formula wherein the general symbols are as defined in claim1, as stabilisers for protecting organic materials, in particular polymers and lubricants, against thermal, oxidative or light-induced degradation.

Process for the preparation of 3-aryl-benzofuran-2-ones

The instant invention discloses a process for the preparation of compounds of formula I wherein the general symbols are as defined in claim 1, which process comprises hydrolyzing a compound of formula V wherein the general symbols are as defined in claim 1, in an aqueous solvent in the presence of an acid. The compounds of the formula V are new and useful as stabilizers for protecting organic materials, in particular polymers and lubricants, against oxidative, thermal or light-induced degradation.

A versatile new synthesis of 3-aryl-3H-benzofuran-2-ones

Aromatic or heteroaromatic hydrocarbons are easily alkylated with 3- hydroxy-3H-benzofuran-2-ones under Friedel-Crafts or acid catalysis to afford 3-aryl-3H-benzofuran-2-ones in good yield. Access to the starting 3-hydroxy- 3H-benzofuran-2-ones is easily achievable by reaction of suitably substituted phenols with glyoxylic acid.