164408-13-3Relevant academic research and scientific papers
SYNTHESIS OF SOME NEW FUSED SPIROHETEROCYCLIC SYSTEMS RELATED TO THIAZOLOPYRANS, THIAZOLOTHIOPYRANS AND THIAZOLOPYRIDINES
Al-Ahmadi, Abdullah A.,El-Zohry, Maher F.
, p. 35 - 46 (2007/10/02)
1-Oxa-4-thiaspirononan-2-one and/or 1-oxa-4-thiaspirodecan-2-one were reacted with aniline to give the corresponding spirothiazolidinones (1a,b). Reaction of 1a,b with chalcones yielded 2-(α-aracylbenzyl)-4-phenyl-1-thia-4-azaspirononan-3-one and 2-(α-aracylbenzyl)-4-phenyl-1-thia-4-azaspirodecan-4-one (2a-h). Compounds 2a-h were reacted with acetic anhydride, phosphorus pentasulfide and ammonium accetate to give spirothiazolopyrans 3a-h, spirothiazolothiopyrans 4a-h and spirothiazolodihydropyridines 5a-h respectively. All the synthesized spiroheterocycles derivatives were identified by conventional methods (IR, 1H-NMR) and elemental analyses. Key words: Spirothiazolopyrans, spirothiazolothiopyrans, spirothiazolidihydropyridines, spiroheterocycles, NMR.
