16451-77-7

Upstream product

• 91-21-4 1,2,3,4-tetrahydroisoquinoline 
• 17082-13-2 α-bromoacetophenone oxime 
• 14181-72-7 2-bromo-1-phenyl-ethanone oxime 
• 40814-66-2 (Z)-2-chloro-1-phenylethan-1-one oxime 

Downstream Products

• 87773-10-2 2-Phenyl-5,6-dihydro-imidazo<2,1-a>isochinolin 
• 107183-01-7 (Z)-2-(2-Hydroximino-2-phenyl-ethyl)-1,2,3,4-tetrahydro-1-isochinolin 
• 107182-90-1 2-Phenyl-6,7-dihydro-4H-isochino<2,1-e>-1,2,5-oxadiazin 
• 107182-89-8 2-Phenyl-5,6-dihydro-3H-imidazo<2,1-a>isochinolin-1-oxid 

Relevant academic research and scientific papers

STEREOCHEMISTRY OF α-AMINOACETOPHENONE OXIMES STUDY OF SOLVENT EFFECTS

The aminolysis of Z-α-halogenoacetophenone oximes results in different mixtures of E- and Z-α-aminoacetophenone oximes depending on the solvent used.Assignment of configuration can be achieved by 13C NMR spectroscopy even if only one isomer is available using a strong solvent dependence of the methylene chemical shift in the case of the Z-isomers.This effect is due to the presence of different conformations in the solvents chloroform and dimethyl sulfoxide.Together with a study by vapor pressure osmometry the results provide an unambiguous proof of intramolecular hydrogen bonding of Z-α-aminoacetophenone oximes in chloroform.