164534-02-5Relevant articles and documents
Enantio- and diastereoselective synthesis of the AB ring system of aklavinone by coupling a chemoenzymatic procedure with organometal chemistry
Banfi, Luca,Guanti, Giuseppe,Riva, Renata
, p. 13493 - 13512 (2007/10/03)
Two different approaches were investigated in order to prepare the title compound 2; best results were obtained when the tandem reduction/intramolecular hydroxyalkylation of the appropriate 5-alkoxy-(3-hydroxyphenyl)pentanoate was performed on an ester of chemoenzymatic origin, already bearing the two chiral centers present in 2 with the correct relative and absolute stereochemistry.
Enantioselective Synthesis of the AB ring System of Aklavinone Via a Chemoenzymatic Route
Guanti, Giuseppe,Riva, Renata
, p. 3933 - 3936 (2007/10/02)
The AB ring system 2 of aklavinone 1 was obtained using a chemoenzymatic protocol.Key steps are the stereoselective addition of lithium enolate of ethyl acetate to ketone 13 and the intramolecular Freiedel-Crafts reaction to give tetralin 17.
